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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
INHIBITORY ACTIVITY OF VITAMIN C ON THE SUSCEPTIBILITY OF ALBUMIN TO GLYCATION REACTION
Authors
1Laboratory Medicine Department, Paramedicine Faculty, Hamadan University of Medical Sciences & Health Services, [email protected], Iran
*Corresponding Author: Laboratory Medicine Department, Paramedicine Faculty, Hamadan University of Medical Sciences & Health Services, [email protected], Iran. Email: [email protected]
Published online:Mar 30, 2007
Article type:Research Article
Received:Oct 12, 2006
Accepted:Apr 14, 2007
How to Cite:Safari M. INHIBITORY ACTIVITY OF VITAMIN C ON THE SUSCEPTIBILITY OF ALBUMIN TO GLYCATION REACTION. Jundishapur J Nat Pharm Prod. 2007;2(1):. doi:
Abstract
Vitamin C, a water soluble antioxidant, can react with amino groups of proteins to form schiff bases. As diabetes leads to glycation of various proteins which has effect on structure and biochemical activity of them , the inhibition of this process seems very vital. For several years researches in this field have done their best to recognize the antidiabetics compounds. The aim of this study is to determine the effects of vitamin C on albumin glycation in vitro. So in the presence of various concentration of vitamin C, albumin was glycated and evaluated using TBA method. The results showed that vitamin C significantly (P<0.05) inhibit or decrease the reaction of albumin glycation. The findings of this research showed that vitamin C probably inhibit the reaction of glycation and decrease complications occurring in diabetes.
Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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