Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
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A single-nucleotide polymorphism of GRIN1 in heroin and methamphetamine addicts at a rehabilitation sanatorium in Markazi province, Iran
Author(s):
1Dept. of Biology, Faculty of Science, Arak University, Arak, Iran
*Corresponding Author: Corresponding author: Ahmad Hamta, Dept. of Biology, Faculty of Science, Arak University, Arak, Iran, Tel: +98 9183671016 Email: [email protected]
Published online:Mar 19, 2017
Article type:Research Article
Received:Sep 27, 2016
Accepted:Jan 15, 2017
How to Cite:Hamta A, sahraei M. A single-nucleotide polymorphism of GRIN1 in heroin and methamphetamine addicts at a rehabilitation sanatorium in Markazi province, Iran. J Kermanshah Univ Med Sci. 2017;20(4):e69665. doi: https://doi.org/10.22110/jkums.v20i4.3207
Abstract
Introduction: Using addictive drugs can change the amount of neurotransmitters, especially dopamine and glutamate. Glutamate has been known to trigger the relapse and tendency toward addictive drugs. The glutamate receptor ionotropic NMDA type subunit 1 (GRIN1) contains the single- nucleotide polymorphism C1001G (rs11146020) and encodes N-methyl-D-aspartic acid (NDMA) receptor subunit 1 (NR1). The present study was conducted to investigate the relationship between the rs11146020 polymorphism in GRIN1 and addiction to heroin and methamphetamine.
Methods: The present case-control study recruited 90 male heroin and methamphetamine addicts treated with methadone and 100 healthy men. Genomic DNA was extracted from peripheral blood using Iraizol kits. Four pairs of specific primers were designed using AlleleID 7.5, and the T-ARMS PCR was optimized.
Results: The genotype distribution of GG, GC and CC was respectively found to be 66%, 31% and 3% in the control group and 58%, 31% and 11% in the patient group. The statistical analysis suggested no significant differences between these two groups.
Conclusion: No significant relationships were observed between the C1001G polymorphism in GRIN1 and addiction to heroin and methamphetamine.
References
- 1.The references of this article is available on PDF.
Copyright
© 2017, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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