Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
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Effect of crocin on reducing the number of embryos and implantation sites in mice
Author(s):
1Dept. of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Seyed Ershad Nedaei, Dept. of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, Tel: +9183397982 Email: [email protected]
Published online:Nov 19, 2015
Article type:Letter
Received:Jun 22, 2015
Accepted:Oct 06, 2015
How to Cite:Pourmotabbed A, Nedaei SE, Javidi Helan S, Jalili C, Khazaei M. Effect of crocin on reducing the number of embryos and implantation sites in mice. J Kermanshah Univ Med Sci. 2015;19(5):e69828. doi: https://doi.org/10.22110/jkums.v19i5.2646
Abstract
Background: Crocin is one of the main components of saffron. The effect of saffron on birth abortion has been established. So, the possible effect of crocin on abortion was evaluated in this study.
Methods: Pregnant mice were divided into 8 groups. Each group received crocin (0 or 10 or 50 or 100 mg/kg, i.p.) from the first to the fifth day of pregnancy. Then, the first four groups were sacrificed on the seventh day to evaluate the implantation sites. The other four groups were sacrificed on the 20th day and the number of embryos was counted. Data were analyzed by ANOVA.
Results: Administration of crocin (50 and 100 mg/kg) significantly reduced the mean number of implantation sites and embryos compared to the control group (P<0.05).
Conclusion: Administration of high doses of crocin in the first week of pregnancy reduced the number of implantation places and embryos in mice.
References
- 1.The references of this article is available on PDF.
Copyright
© 2015, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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