Antibacterial Effect of Combination of Cinnamon Essential Oil and Thymol, Carvacrol, Eugenol, or Geraniol

Yassine El Atki; Imane Aouam; Amal Taroq; Fatima El Kamari; Mohammed Timinouni; Badiaa Lyoussi; Abdelfattah Abdellaoui

doi:10.4103/jrptps.JRPTPS_25_19

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https://doi.org/10.4103/jrptps.JRPTPS_25_19

Antibacterial Effect of Combination of Cinnamon Essential Oil and Thymol, Carvacrol, Eugenol, or Geraniol

Author(s):

Yassine El Atki^1,*,

Imane Aouam¹,

Amal Taroq¹,

Fatima El Kamari¹,

Mohammed Timinouni²,

Badiaa Lyoussi¹,

Abdelfattah Abdellaoui¹

1Department of Biology, Laboratory of Physiology Pharmacology and Environmental Health, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco

2Molecular Bacteriology Laboratory, Pasteur Institute of Morocco, Casablanca, Morocco

Journal of Reports in Pharmaceutical Sciences:Vol. 9, issue 1; 104-9

Published online:Jun 26, 2020

Article type:Research Article

Received:Mar 18, 2019

Accepted:Oct 06, 2019

How to Cite:El Atki Y, Aouam I, Taroq A, Kamari FE, Timinouni M, et al. Antibacterial Effect of Combination of Cinnamon Essential Oil and Thymol, Carvacrol, Eugenol, or Geraniol. J Rep Pharm Sci. 2020;9(1):e147305. doi: https://doi.org/10.4103/jrptps.JRPTPS_25_19

Abstract

Bacterial resistance to classic antibiotics is an alarming rate to put this into control with the use of natural products of plant derivatives. The objective of this study was to determine the phytochemical of cinnamon essential oil (EO) and to evaluate its antibacterial activity alone and in combination with some main components of EOs such as thymol, carvacrol, eugenol, or geraniol against three bacterial strains (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). The phytochemical analysis of cinnamon EO was evaluated using gas chromatography-flame ionization detector and gas chromatographymass spectrometer analysis. The antibacterial activity of tested compounds was determined by agar disk diffusion and minimum inhibitory concentration (MIC) assays. The checkerboard method was used to quantify the efficacy of cinnamon EO in combination with those compounds. The results showed that the major compound in the cinnamon EO was trans-cinnamaldehyde (91.01%). Cinnamon oil was the highest antibacterial activity with MIC of 0.005, 0.005, and 0.02 mg/mL against E. coli, S. aureus, and P. aeruginosa, respectively. Synergistic activity was shown only against S. aureus by the combination of cinnamon EO and thymol. The additive effect was found against E. coli when cinnamon EO was combined with thymol or carvacrol, and against S. aureus when cinnamon EO was combined with carvacrol. However, the combination of EO and thymol or carvacrol showed an indifference action against P. aeruginosa. The combination of cinnamon EO with thymol or carvacrol can be used as an alternative therapeutic agent for medical application and as a natural preservative.

Keywords

antibacterial activity

cinnamon

combination

gas chromatography-mass spectrometer analysis

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Author(s):

Yassine El Atki:[PubMed][Scholar]
Imane Aouam:[PubMed][Scholar]
Amal Taroq:[PubMed][Scholar]
Fatima El Kamari:[PubMed][Scholar]
Mohammed Timinouni:[PubMed][Scholar]
Badiaa Lyoussi:[PubMed][Scholar]
Abdelfattah Abdellaoui:[PubMed][Scholar]

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Antibacterial Effect of Combination of Cinnamon Essential Oil and Thymol, Carvacrol, Eugenol, or Geraniol

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Last Update: 2 weeks ago

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