Journal of Reports in Pharmaceutical Sciences
The Anti-Atherosclerotic Effect of Prosopis Farcta is Associated with the Inhibition of VCAM-1 and ICAM-1
Gholamreza Bahrami1, 2, Leila Hosseinzadeh3, Zahra Azadi4, Bahareh Mohammadi1, Zahra Mahdiyan4, Marziyeh Hajialyani3, MohammadHossein Farzaei
2, 3,*Abstract
This study evaluated the anti-atherosclerosis effect of aqueous extract and polysaccharide-enriched fraction of Prosopis farcta on adhesion and inflammatory cascades in vascular endothelial cells and related molecular mechanisms. Cellular toxicities of LPS, plant extract and polysaccharide-enriched fraction were analyzed in vitro using the MTT method. The ROS accumulation, mRNA expression of ICAM1 and VCAM1, and COX activity were measured in HUVEC cells. These results revealed a new underlying mechanism for anti-atherosclerosis effect of P. farcta and polysaccharide-enriched fraction by attenuating inflammatory cascade mediated by COX expression, modulating expression of cell-adhesion molecules including VCAM-1 and ICAM-1, and diminishing oxidative stress agents.
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© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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