Effect of Tribulus Terrestris Aqueous Extract on Survival and Growth of Human Peripheral Blood Mononuclear Cells (Hpbmc) and Several Cancerous Cell Lines
Authors
Abstract
Tribulus terrestris (TT) is a member of the Zygophyllaceae family. Traditional Chinese medicine recommends the use of TT for treatment of a variety of diseases. In the present study we further investigated antiproliferative and cytotoxic effects of TT extract on normal and several malignant cell lines. For this purpose, TT was collected and after authentication, aqueous extract was prepared. Cytotoxic activity of TT extract at different doses (5-640μg/ml) was determined by LDH assay. Proliferative activity of TT extract was determined by trypan blue staining and cell counting methods. The results showed that IC50 of the extract for cancer cell line is 320 μg/ml and it is higher for hPBMC. On the other hand, we observed proliferative effect of TT extract on hPBMC but not on malignant cell lines.
Highlights
Copyright
© 2015, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines
Pourali M, Yaghoobi MM, Salehi Sormaghi MH. Cytotoxic, Anti-Proliferative and Apoptotic Effects of Tribulus terrestris L. Fruit Extract on Human Prostate Cancer Lncap and Colon Cancer HT-29 Cell Lines. Jundishapur J Nat Pharm Prod. 2017;12(2):e33561. doi: https://doi.org/10.5812/jjnpp.33561
Effect of aqueous extract of Tribulus terrestris on the activity of major platelets factors and the treatment of immune thrombocyto-penic purpura
Aghapour S, Mostafaie A, Payandeh M, Mansouri K, Sohrabi F, et al. Effect of aqueous extract of Tribulus terrestris on the activity of major platelets factors and the treatment of immune thrombocyto-penic purpura. Compr Health Biomed Stud. 2022;1(1):e142856. doi: https://doi.org/10.22034/hmrj.2021.139993
Synergistic Antimicrobial Effect of Tribulus terrestris and Bitter Almond Extracts
Abtahi H, Ghazavi A, Karimi M. Synergistic Antimicrobial Effect of Tribulus terrestris and Bitter Almond Extracts. Zahedan J Res Med Sci. 2014;16(12):e2000. doi:
The Effects of Tribulus Terrestris Extract and Endurance Training on Oxidative Stress and Apoptotic Markers in the Kidney Tissue of Rats, Poisoned with Arsenic
Farokhi F, Peeri M, Azarbayjani MA, Hosseini SA. The Effects of Tribulus Terrestris Extract and Endurance Training on Oxidative Stress and Apoptotic Markers in the Kidney Tissue of Rats, Poisoned with Arsenic. Gene Cell Tissue. 2023;10(3):e131298. doi: https://doi.org/10.5812/gct-131298
The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with B-Chronic Lymphocytic Leukemia
Hemati M, Abdollahi M, Pashaei M, Ghahremanfard F, Kokhaei P. The effect of Thymoquinone on Peripheral Blood Mononuclear Cells (PBMCs) viability of patients with B-Chronic Lymphocytic Leukemia. koomesh. 2023;25(2):e152812. doi:
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 1
Last Update: 1 week ago
- Scopus by Title (Ref): 1
Last Update: 1 week ago
- CrossRef: 0
Last Update: 7 hours ago
- OpenAlex: 0
Last Update: 9 hours ago
- OpenCitations: 0
Last Update: 5 days ago