Journal of Semnan University of Medical Sciences
Image Credit:Koomesh
Outline
Toxocariasis antibody tittering in patients with uveitis
Authors
Abstract
Introduction: Toxocariasis is a zoonotic disease caused by the infection of human with second-stage larvae of Toxocaraspecies. The three main human syndromes are visceral larva migrans (VLM), ocular larva migrans (OLM), and covert toxocariasis. The aim of this study was to determine the anti body titer against Toxocara in patients with uveitis. Materials and Methods: A total of 161 uveitis patient’s blood ;Serum were collected from patients referred to training hospitals Universities in Tehran. CBC was performed to determine the presence of hyper eosinophilia. Sera was examined by ELISA to determine Toxocaracanis antibody titer. The positive sera samples were confirmed by westernblot test. Results: One hundred and twenty four uveitis patients were male and 127 were female. Sera samples (n=10, %6/2) were positive for T.canis IgG, including 9 (%7/3) male samples and 1(%2/7) female sample. Nine of sera samples from 10 ELSA positive samples were confirmed for 24-35 KDa bands on nitrocellulose membrane that reconfirmed the Toxocaracanis infection and 1 sample was negative. Conclusion: The mentioned results imply that the ocular toxocariasis exists in Iran and the children are more vulnerable to the disease. Therefore, its necessary to measure the antibody against Toxocaracanis in uveit patients by ELISA test and positive patients should be treated before implicating with irreversible signs and symptoms.
Highlights
References
- 1.Markell E, Voges M. Medical Parasitology.9th ed. Sunders Elsevier 2005; 310-312.
- 2.Neva A, Brown W. Basic clinical parasitology. translated by athari A. 5th ed. Ayeej 2000; 160: 397-403. (Persian).
- 3.Schmidt GD, Robers LS. Foundation of parasitology.4th ed. Times mirror/Mosb college publishing 1989; 455-460.
- 4.Waklelin D, Gillespi SH, Despommie DD. Topley&Wilsons parasitology.10th edition. Edward Arnold Ltd 2005.
- 5.Muller R.Worms and Human Disease,2nd Edition. CAB International 2002.
- 6.Pivetti-Pezzi P. Ocular Toxocariasis. Int J Med Sci 2009; 6: 129-130.
- 7.De Visser L. Infectious uveitis, New developments in etiology and pathogenesis. 2009.
- 8.Javadi M, Ahmadi K. Principles of ophthalmology. 2th ed. Nashre tabib press 2002.
- 9.Sudharshan S, Ganesh SK, Biswas J. Current approach in the diagnosis and management of posterior uveitis. Indian J Ophthalmol 2010; 58: 29-43.
- 10.Shields J, Ocular toxocariasis. A review. Survey of ophthalmology. 1984; 28.
- 11.Lim SJ, Lee SE, Kim SH, Hong SH, You YS, Kwon OW, Kim HS. Prevalence of Toxoplasma gondii and toxocara canis among patients with Uveitis. Ocul Immunol Inflamm 2014; 22: 360-366.
- 12.Pollard ZF, Jarrett WH, Hagler WS. ELISA For diagnosis of ocular toxocariasis.
- 13.Logar J, Soba B, Kraut A, Stirn-Kranjc B. Seroprevalence of Toxocara antibodies among patients suspected of oculartoxocariasis in Slovenia. Korean J Parasitol 2004; 42: 137-140.
- 14.De Visser L, Rothova A, De Boer JH, Van Loon AM, Kerkhoff FT, Canninga-van Dijk MR. Diagnosis of ocular toxocariasis by establishing intraocular antibody production. Am J Ophthalmol 2008; 145: 369-374.
- 15.Mikaniki E. Ocular toxocariasis in 40 years old man. J Mubabol 2006; 67-69. (Persian).
- 16.Moradian S, Parchegani MR. Ocular Toxocariasis in a young man. Bina J Ophthalmol 2009; 14: 177-180.
- 17.Fallah E, Javaddeh A, Mahami M. Ocular toxocariasis in 11 years old girl. Med J Tabriz 2011; 107-110. (Persian).
- 18.Khazan H, Nasiri M, Sayyed N. Serological survey of toxocariasis in eye paients referring to Labbafinejad and Farabi hospitals in Tehran, Iran. 2005. (Persian).
Copyright
© 2016, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Frequency of Toxocariasis Among Asthmatic Children in Northeastern Iran
Shamsian SA, Sayedi SJ, Zibaei M, Vaghei S, Moghaddas E. Frequency of Toxocariasis Among Asthmatic Children in Northeastern Iran. Arch Clin Infect Dis. 2019;14(6):e82967. doi: https://doi.org/10.5812/archcid.82967
A Comparative Seroprevalence Study of Toxocariasis in Hypereosinophilic and Apparently Healthy Individuals
Sarkari B, Lari M, Shafiei R, Sadjjadi SM. A Comparative Seroprevalence Study of Toxocariasis in Hypereosinophilic and Apparently Healthy Individuals. Arch Pediatr Infect Dis. 2015;3(2):e17911. doi: https://doi.org/10.5812/pedinfect.17911
Frequency of Antitoxocara Antibodies in Students with Chronic Cough and Eosinophilia in a Rural Area of Shiraz, Iran
Ghorbani-Ranjbary A, Ghorbani-Ranjbary N, Varzandian S, Ghorbani-Ranjbary Z. Frequency of Antitoxocara Antibodies in Students with Chronic Cough and Eosinophilia in a Rural Area of Shiraz, Iran. Zahedan J Res Med Sci. 2015;17(1):e1921. doi:
Seroprevalence of Toxocariasis Among Hypereosinophilic Children: A Single Center Study, Tehran, Iran
Sharifdini M, Zarean M, Sadredinamin M, Zare- Bavani M, Sharifi-yazdi S, et al. Seroprevalence of Toxocariasis Among Hypereosinophilic Children: A Single Center Study, Tehran, Iran. Arch Pediatr Infect Dis. 2022;11(1):e123107. doi: https://doi.org/10.5812/pedinfect-123107
Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran
Sadri H, Gharavi MJ, Arjmand R, Zibaei M, Elahimehr N, et al. Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran. Arch Pediatr Infect Dis. 2019;7(2):e82370. doi: https://doi.org/10.5812/pedinfect.82370
- Scopus by DOI: 0
Last Update: 4 days ago
- Scopus by Title: 6
Last Update: 4 days ago
- Scopus by Title (Ref): 6
Last Update: 4 days ago
- CrossRef: 0
Last Update: 5 hours ago
- OpenAlex: 0
Last Update: 7 hours ago
- OpenCitations: 0
Last Update: 4 days ago