Journal of Semnan University of Medical Sciences
Endothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats
Authors
,*, Torandokht BalochMojaradAbstract
Introduction: Quercetin is one of the most common forms of flavonoids in foodstuffs, which could have multiple beneficial effects on the cardiovascular system including an induction of vasorelaxation in conductance and resistive vessels. Due to changes in endothelial functionality in diabetes mellitus, there is an enhanced vascular responsiveness to contractile agonists. Therefore, the role of endothelium was evaluated in vasorelaxant effect of quercetin in diabetic rats. Materials and Methods: For this purpose, male Wistar rats were divided into control and diabetic groups. For induction of diabetes, streptozotocin (60 mg/Kg, i.p.) was used. The body weight and serum glucose parameters were determined before and at 2nd and 4th after the experiment. Contractile responsiveness to KCl and noreadrenalin (NA) and quercetin-induced vasorelaxation were measured at the end of study. Results: After 4 weeks, quercetin (1 mM-10 mM) induced a dose-dependent vasorelaxation in aortic rings precontracted with KCl andor NA from both control and diabetic groups (p
Copyright
© 2005, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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