The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats
Authors
Abstract
In this study, the possible involvement of L-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. Addition of quercetin (0.1 µM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings and nifedipine attenuated this response, especially for noradrenaline (P<0.05). It is concluded that the flavonoid quercetin produces a potent relaxation of the rat aorta and blockade of voltage-operated calcium channels could attenuate this effect.
Highlights
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Examination of the Role of Potassium Channels in the Relaxant Effects of Quercetin on Intestinal Smooth Muscle Contractions
Sadraei H, Bahrami F, Ghasemi M. Examination of the Role of Potassium Channels in the Relaxant Effects of Quercetin on Intestinal Smooth Muscle Contractions. Koomesh. 2025;27(6):e157890. doi: https://doi.org/10.69107/koomesh-157890
Endothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats
Roghani M, BalochMojarad T. Endothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats. koomesh. 2005;6(3):e152058. doi:
Effects of L-type Calcium Channel Antagonists Verapamil and Diltiazem on fKv1.4ΔN Currents in Xenopus oocytes
Chen H, Zhang D, Hua Ren J, Ping Chao S. Effects of L-type Calcium Channel Antagonists Verapamil and Diltiazem on fKv1.4ΔN Currents in Xenopus oocytes. Iran J Pharm Res. 2013;12(4):e125756. doi: https://doi.org/10.22037/ijpr.2013.1361
Spasmolytic Effect of Vitis Vinifera Leaf Hydroalcoholic Extract on Rat's Isolated Vas Deferens
Gharib-Naseri M, Vakilzadeh G. Spasmolytic Effect of Vitis Vinifera Leaf Hydroalcoholic Extract on Rat's Isolated Vas Deferens. J Kermanshah Univ Med Sci. 2005;9(1):e81513. doi:
Lovastatin Incubation Improves Acetylcholine-Induced Relaxation in Isolated Aortic Rings of Diabetic Rat
Parsaee H, Imenshahidi M, Fatehi Z. Lovastatin Incubation Improves Acetylcholine-Induced Relaxation in Isolated Aortic Rings of Diabetic Rat. Iran J Pharm Res. 2022;5(3):e128284. doi: https://doi.org/10.22037/ijpr.2010.674
More by these authors
- Scopus by DOI: 6
Last Update: 3 weeks ago
- Scopus by Title: 6
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 7
Last Update: 5 hours ago
- OpenCitations: 0
Last Update: 4 days ago