Journal of Semnan University of Medical Sciences
Preventive effects of an oral rinse Peppermint essence on chemotherapy-induced oral mucosistis
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Abstract
Introduction: Oral mucositis (OM) is a significant and frequent complication of chemotherapy, which results in delayed or incomplete chemotherapeutic management. This study was conducted to determine the effects of an oral rinse Peppermint essence (PE) in the prevention of chemotherapy- induced OM Materials & Methods: In this double blind clinical trial, 40 patients with colon or rectum cancers, who admitted for chemotherapeutic management, randomly divided in two equal placebo and PE groups. PE and placebo groups were received 10 drops of oral rinse PE or placebo, three times a day, from the first day of chemotherapy up to the fourteenth day, respectively. A bipartite questionnaire was used for obtaining demographic and clinical information. The evaluation of OM was measured using the WHO scale. Content and inter-rater methods were used for validity and reliability of tools, respectively (r = 0.93). Results: The incidence of OM between the PE group (15%) and the placebo group (50%) was significantly different (p
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© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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