Journal of Semnan University of Medical Sciences
Neuroprotective effects of voluntary exercise and hydroalcoholic extraction of Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of parkinsonian rats
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Abstract
Introduction: In this study, we investigated the effects of 12 weeks of voluntary exercise on a running wheel and extraction of plant flowers Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of Parkinsonian rats. Materials and Methods: Twenty four rats were divided into three groups: control, Parkinson and Parkinson + training and extract. To induce Parkinson, 250 mg/kg of 6-hydroxy dopamine (6-OHDA) (dissolved in saline) was administered into intracerebrovenricular by a stereotaxic apparatus. Training-extract group were housed in individual cages with attached running wheels and during study period received 200 mg/kg extract intraperitoneally three times per week. Tyrosine hydroxylase and dopamine levels in the striatum were measured by ELISA. Results: Voluntary wheel running and extract significantly prevent the decrease of dopamine levels in Parkinsonian rats (P = 0.001), but tyrosine hydroxylase level did not change in training-extract group. Conclusion: Our findings show that pre-treatment with voluntary exercise and hydroalcoholic extractions of Eriobotrya Japonica have a protective role against 6-OHDA induced toxicity
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© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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