Journal of Semnan University of Medical Sciences
Effect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats
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Abstract
Introduction: Carnosine is an endogenous dipeptide expressed in many tissues including brain and has a protective effect against ischemic brain damage. However, its effect on brain edema, which is one of the most important variables in determining the amount of secondary brain damage after stroke, is not clear. The present study was conducted to investigate the effect of L-Carnosine on brain edema and oxidative stressbiomarkers in an experimental model of focal cerebral ischemia. Materials and Methods: Under Laser Doppler flowmetry, cerebral ischemia was induced by transient occlusion of middle cerebral artery for 1 hour in rats. L-Carnosine at doses of 250 and 500 mg/kg.ip was injected immediately after induction of ischemia. Cerebral edema and enzymes activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) content were measured 24 hours after ischemia using a standard method and kit. Results: Administration of L-Carnosine at doses 250(%81.5±0.36) and 500 (%80.9±0.30) mg/kg significantly reduced brain edema by 25% and 40% in comparison with the control group (%82.53±0.16), respectively (P
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© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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