Cover image of the article: Effects of intermittent and continuous injections of oxytocin on labor time and maternal and neonatal outcomes in normal delivery

Image Credit:Koomesh

Effects of intermittent and continuous injections of oxytocin on labor time and maternal and neonatal outcomes in normal delivery

Authors

Maryam Sina, Mojgan Rahmanian,*, majid mirmohammadkhani
*Corresponding Author: Email: rahmanian_74@yahoo.com

Koomesh:Vol. 20, issue 4; 633-637
Published online:Mar 07, 2018
Article type:Research Article
Received:Oct 03, 2017
Accepted:May 07, 2018
How to Cite:Sina M, Rahmanian M, mirmohammadkhani M. Effects of intermittent and continuous injections of oxytocin on labor time and maternal and neonatal outcomes in normal delivery. koomesh. 2018;20(4):e153004. doi:

Abstract

Introduction: Several studies have shown that long-term use of oxytocin for inducting or enhancing labor can reduce the efficacy of induction and increase the rate of complications. The aim of this study was to compare the effect of intermittent and continuous injection of oxytocin on labor time and maternal and neonatal outcomes in normal delivery. Materials and Methods: In this study, 140 patients with an age range of at least 14 and a maximum of 40 years (mean 26.94) were studied. Patients received 10 units of oxytocin at 1000 cc of ringer, initiated at a dose of 2 mU/min, and 2 mU/min was increased every 15 minutes to achieve uterine contractions of 3 to 5 contractions in 10 minutes or a maximum dose of 23 mU/min. At the beginning of the active phase (dilatation 4 cm), the patients were divided into 2 groups. In one group, oxytocin continued until delivery, and in the other group at the beginning of the active phase, oxytocin was discontinued. Results: No significant differences were found between intermittent and continuous oxytocin injected groups in the duration of active phase and Apgar score, cesarean section, admission to NICU and postpartum fever.  Also, there was no relationship between the incidence of abnormal heartbeat and postpartum hemorrhage the method of oxytocin admistration. Only the duration of labor in the intermittent group was significantly higher than the continuous infusion group. Conclusion: This study demonstrates that continuous injections of oxytocin shorten the length of delivery, and consequently reduce the possible complications caused by prolonged time of injection.  

Highlights

References

  • 1.
    Arrowsmith S, Wray S. Oxytocin: its mechanism of action and receptor signalling in the myometrium. J Neuroendocrinol 2014; 26: 356-369.
  • 2.
    Enck P, Klosterhalfen S. The story of Ois oxytocin the mediator of the placebo response? Neurogastroenterol Motil 2009; 21: 347-350.
  • 3.
    Phaneuf S, Asboth G, Carrasco M, Europe-Finner G, Saji F, Kimura T, Harris A, Bernal AL. The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA. J Endocrinol 1997; 154: 7-18.
  • 4.
    Begum LN, Sultana M, Nahar S, Begum R, Barua S. A randomized clinical trial on the need of continuing oxytocin infusion in active phase of induced labour. Chattagram Maa-O-Shishu Hosp Med Coll J 2013; 12: 23-30.
  • 5.
    Yazdiha MS, Ghorbani R, Behshad J, Hoseini SM, Razavi M, Emadi A. Relationship between idiopathic hypercalciuria and urinary tract infection in children of 1-14 years of age. Koomesh 2016; 18: 153-158. (Persian).
  • 6.
    Noripour S, Molaei A, Bandari R, Emadi A, Far SMF, Forozeshfard M. Comparison of the results of simultaneous surfactant administration and nasal continuous positive airway pressure (INSURE) and Non-administration of surfactant for the treatment of infants with respiratory distress syndrome. J Comprehensive Pediatr 2017; 8. (Persian).
  • 7.
    Cunningham F, Leveno K, Bloom S, Spong CY, Dashe J. Williams obstetrics, 24e: Mcgraw-hill; 2014.
  • 8.
    Lee HJ, Macbeth AH, Pagani JH, Young 3rd WS. Oxytocin: the great facilitator of life. Prog Neurobiol 2009; 88: 127-151.
  • 9.
    Mercer B, Pilgrim P, Sibai B. Labor induction with continuous low-dose oxytocin infusion: a randomized trial. Obstet Gynecol 1991; 77: 659-663.
  • 10.
    Ustunyurt E, Ugur M, Ustunyurt BO, Iskender TC, Ozkan O, Mollamahmutoglu L. Prospective randomized study of oxytocin discontinuation after the active stage of labor is established. J Obstet Gynaecol Res 2007; 33: 799-803.
  • 11.
    Blakemore KJ, Qin NG, Petrie RH, Paine LL. A prospective comparison of hourly and quarterhourly oxytocin dose increase intervals for the induction of labor at term. Int J Gynecol Obstet 1990; 33: 387.
  • 12.
    Bahadoran P, Falahati J, Shahshahan Z, Kianpour M. The comparative examination of the effect of two oxytocin administration methods of labor induction on labor duration stages. Iran J Nurs Midwifery Res 2011; 16: 100-105.
  • 13.
    Girard B, Vardon D, Creveuil C, Herlicoviez M, Dreyfus M. Discontinuation of oxytocin in the active phase of labor. Acta Obstet Gynecol Scandinavica 2009; 88: 172-177.
  • 14.
    DanielSpiegel E, Weiner Z, BenShlomo I, Shalev E. For how long should oxytocin be continued during induction of labour? BJOG:2004; 111: 331-334.
  • 15.
    ztrk FH, Ylmaz SS, Yalvac S, Kandemir . Effect of oxytocin discontinuation during the active phase of labor. J Matern Fetal Neonatal Med 2015; 28: 196-198.

Copyright

© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Similar Articles

9
Jul
2024
Determinants of Higher Oxytocin Dose Need During Labor Induction

Determinants of Higher Oxytocin Dose Need During Labor Induction

Soghra Khazardoust,
Raheleh Mahdavi,
Sedigheh Hantoushzadeh,
Marjan Ghaemi,
Hajieh Borna,
Mozhgan Arman
,et al.

Khazardoust S, Mahdavi R, Hantoushzadeh S, Ghaemi M, Borna H, et al. Determinants of Higher Oxytocin Dose Need During Labor Induction. Fertil Gynecol Androl. 2024;4(1):e148579. doi: https://doi.org/10.5812/fga-148579

30
Jun
2025
A Randomized Clinical Trial on the Analgesic Effects of Continuous Low-Dose Oxytocin Infusion After Cesarean Section Performed with Spinal Anesthesia

A Randomized Clinical Trial on the Analgesic Effects of Continuous Low-Dose Oxytocin Infusion After Cesarean Section Performed with Spinal Anesthesia

Marzieh Khezri,
Seyed Mohammad Mehdi Mir-Nasseri,
Nasim Zarrin,
Abbas Allami,
Hamideh Pakniat,
Amirhussein Atlasbaf

Khezri M, Mir-Nasseri SMM, Zarrin N, Allami A, Pakniat H, et al. A Randomized Clinical Trial on the Analgesic Effects of Continuous Low-Dose Oxytocin Infusion After Cesarean Section Performed with Spinal Anesthesia. J Inflamm Dis. 2025;29(2):e164632. doi: https://doi.org/10.69107/jid-164632

1
Jan
1970
Management of Third Stage of Labor: A Comparison of Intraumbilical Oxytocin and Placental Cord Drainage

Management of Third Stage of Labor: A Comparison of Intraumbilical Oxytocin and Placental Cord Drainage

Somayeh Makvandi,
Shirin Zargar Shoushtari,
Vahideh Zaker Hosseini

Makvandi S, Zargar Shoushtari S, Zaker Hosseini V. Management of Third Stage of Labor: A Comparison of Intraumbilical Oxytocin and Placental Cord Drainage. Shiraz E-Med J. 1970;14(2):83-90. doi:

31
Oct
2006
Maternal and Neonatal Oxytocin Levels During Cesarean Section With or Without Labor Pain and Puerperal Complications

Maternal and Neonatal Oxytocin Levels During Cesarean Section With or Without Labor Pain and Puerperal Complications

M Sayyah Melli,
M Alizadeh,
M Rahbani-noubar

Sayyah Melli M, Alizadeh M, Rahbani-noubar M. Maternal and Neonatal Oxytocin Levels During Cesarean Section With or Without Labor Pain and Puerperal Complications. Int J Endocrinol Metab. 2006;4(4):. doi:

19
Sep
2009
A comparison of the effect of nipple stimulation and oxytocin infusion on the duration of phases of labor

A comparison of the effect of nipple stimulation and oxytocin infusion on the duration of phases of labor

Sohila Pirdadeh Beiranvand,
Sohila Akbari,
Seddighe Azhari,
Mahdi Birjandi

Pirdadeh Beiranvand S, Akbari S, Azhari S, Birjandi M. A comparison of the effect of nipple stimulation and oxytocin infusion on the duration of phases of labor. J Kermanshah Univ Med Sci. 2009;13(2):e79800. doi:

More by these authors

Maryam SinaPubMedScholar
Mojgan RahmanianPubMedScholar
majid mirmohammadkhaniPubMedScholar
Share
Cited by
Metrics