Sign in

Shiraz E-Medical Journal

e-ISSN 1735-1391
Authors GuideSubmit manuscript
Cover image of the article: Comparative Study of Therapeutic Effects of Honey and Povidone Iodine in Surgical Wound Healing in Rabbit

Image Credit:Shiraz E-Med J

Outline

Comparative Study of Therapeutic Effects of Honey and Povidone Iodine in Surgical Wound Healing in Rabbit

Authors

N Sakhavar1,*, N Khadem2
1Instructor, Assistant Professor of Obstetrics and Gynecology, Zahedan University of Medical Science, Zahedan, Iran
2Associate Professor of Obstetrics and Gynecology, Mashhad University of Medical Science, Mashhad, Iran
*Corresponding Author: Department of Obstetrics & Gynecology, Ali Ebne Abitaleb Hospital, Zahedan, Iran, nsakhavar@yahoo.co.uk. Tel: +98-9155419369. Email: nsakhavar@yahoo.co.uk
Shiraz E-Medical Journal:Vol. 9, issue 4; 182-187
Published online:Oct 01, 2008
Article type:Research Article
Received:Feb 16, 2008
Accepted:Aug 15, 2008
How to Cite:Sakhavar N, Khadem N. Comparative Study of Therapeutic Effects of Honey and Povidone Iodine in Surgical Wound Healing in Rabbit. Shiraz E-Med J. 2008;9(4):. doi:

Abstract

Introduction:

Duration and remainder scar are two important problems in process of surgical wound healing, especially in low midline incisions that usually have more duration and wider scar in their healing process. The aim of this study was a comparison between Honey and Povidone Iodine in surgical wound healing, because of Honey is the worlds oldest known wound dressing and there are several reports from its antibacterial properties and stimulating effects on wound healing process.

Materials and Methods:

This clinical trial study was performed on 40 female Rabbits that were non-pregnant, 5 months aged with average weight of 1900 grams, belonging to Albino race, in Animal Institute in Tehran, Iran in the year 2006. For beginning, Rabbits were divided into two equal groups randomly, and then similar surgical incisions 10 cm traced were applied after appropriate shaving and local anesthesia on exterior area of right thigh of all rabbits. Then all Rabbits wounds sutured by Silk 2.0 separately and were covered similarly. Covering of wounds in two groups were changed every 12 hours and wounds were dressed with 5 ml of purred natural Honey in first group and in the second group irrigated with 5 ml of Povidone Iodine 10% in every time. The findings were recorded and analyzed with SPSS software by using of chi-square and t test, p<0.05 was considered as significant.

Results:

Appropriate wound healing in Rabbits 4 days after surgery was significantly different in Honey and Povidone Iodine groups (17/20 or 85% vs. 8/20 or 40%, p=0.0032), in 7th days after surgery this differentiation was significant also (20/20 or 100% vs 11/20 or 55%, p=0.0072). Width of scar 2 weeks after surgery was significantly different in two groups too (2mm SD1 vs. 5mm SD 1, p= 0.0043).

Conclusion:

Use of Honey as wound dressing after surgery reduces duration of healing and width of scar more than Povidone Iodine and its a good alternative for stimulating and improvement of surgical wound healing.

Highlights

KeywordsHoneyPovidone Iodinesurgical wound healing

Full Text

Full text is available in PDF

Copyright

© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Similar Articles

10
Aug
2014
Wound Healing Effect of an Ointment Made From a Mixture of Brassica oleracea var, Punica granatum, and Plantago major L Extracts in Rats

Wound Healing Effect of an Ointment Made From a Mixture of Brassica oleracea var, Punica granatum, and Plantago major L Extracts in Rats

Mohammad Hassan Bazafkan,
Ameneh Hardani,
Mohammad Reza Afzal Zadeh,
Ashraf Amir Zargar,
Mahmoud Orazi Zadeh,
Ali Asghar Hemmati
,et al.
PDF

Bazafkan MH, Hardani A, Afzal Zadeh MR, Amir Zargar A, Orazi Zadeh M, et al. Wound Healing Effect of an Ointment Made From a Mixture of Brassica oleracea var, Punica granatum, and Plantago major L Extracts in Rats. Jentashapir J Cell Mol Biol. 2014;5(4):e21877. doi: https://doi.org/10.17795/jjhr-21877

29
May
2015
The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats

The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats

Nematollah Ghaibi,
Mohammad Sofiabadi,
Amir Farzam,
Mina Homayonizade,
Monireh Sadat Afzali Arani
PDF

Ghaibi N, Sofiabadi M, Farzam A, Homayonizade M, Afzali Arani MS. The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats. J Kermanshah Univ Med Sci. 2015;19(2):e69886. doi: https://doi.org/10.22110/jkums.v19i2.2195

31
Jul
2012
Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Mostafa Feghhi,
Mansour Amin,
Mitra Zamani,
Danial Najdi
PDF

Feghhi M, Amin M, Zamani M, Najdi D. Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits. Jundishapur J Microbiol. 2012;5(3):. doi: https://doi.org/10.5812/jjm.4129

31
Mar
2017
Evaluation of the Wound Healing Activity of a Traditional Compound Herbal Product Using Rat Excision Wound Model

Evaluation of the Wound Healing Activity of a Traditional Compound Herbal Product Using Rat Excision Wound Model

Maryam Jahandideh,
Homa Hajimehdipoor,
Seyed Alireza Mortazavi,
Ahmadreza Dehpour,
Gholamreza Hassanzadeh
PDF

Jahandideh M, Hajimehdipoor H, Mortazavi SA, Dehpour A, Hassanzadeh G. Evaluation of the Wound Healing Activity of a Traditional Compound Herbal Product Using Rat Excision Wound Model. Iran J Pharm Res. 2017;16(Suppl):e124919. doi: https://doi.org/10.22037/ijpr.2017.1990

31
Jul
2017
Comparing the Effects of Topical Application of Honey and Nitrofurazone Ointment on the Treatment of Second-degree Burns with Limited Area: a randomized clinical trial

Comparing the Effects of Topical Application of Honey and Nitrofurazone Ointment on the Treatment of Second-degree Burns with Limited Area: a randomized clinical trial

Tooran Bagheri,
Mohammad Javad Fatemi,
Seyed Abouzar Hosseini,
Mohsen Saberi,
Mitra Niazi,
Mahnoush Momeni
,et al.
PDF

Bagheri T, Fatemi MJ, Hosseini SA, Saberi M, Niazi M, et al. Comparing the Effects of Topical Application of Honey and Nitrofurazone Ointment on the Treatment of Second-degree Burns with Limited Area: a randomized clinical trial. Med Surg Nurs J. 2030;5(4):e67931. doi:

More by these authors

N SakhavarPubMedScholar
N KhademPubMedScholar

Find related work

PubMed
Google Scholar
Create citation alert
Download PDF482.81 KBAbstract XML
Share
Cited by
Metrics
Comments
Number of Comments:0