Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

How to Cite:Feghhi M, Amin M, Zamani M, Najdi D. Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits. Jundishapur J Microbiol. 2012;5(3):. doi: https://doi.org/10.5812/jjm.4129

Abstract

Background: Corneal ulcer is a common cause of blindness in developing countries, as itleads to corneal perforation and blindness if not properly treated.
Objectives: This study aimed to determine the effects of intraocular 5 % and 10 % topical povidone iodine in the treatment of bacterial corneal ulcer in a rabbit model, comparing the effectiveness of vancomycin and cefazolin eye drops.
Materials and Methods: Total of 40 eyes ofrom 20 wild rabbits were randomly assigned to four equal groups, five in each (n = 5), they included; group 1. 5 % povidone iodine and vancomycin; group 2.5 % povidone iodine and cefazolin; group 3.10 % povidone iodine and vancomycin; group 4.10 % povidone iodine and cefazolin (one drop every two hours for seven days and nights). The animals were first anesthetized with ketamine hydrochloride and xylazine chloride. Then, a 27-gauge needle attached to a 1-ml syringe was tunneled through the clear cornea to approximately midstromal depth, stopping at the edge of the 2-mm optical zone. Finally, 0.02 ml of Staphylococcus contaminated media containing about 100 organisms was injected, forming a central intra-stromal infiltrate.
Results: There was no statistically significant difference in the density of infiltration, size of infiltration, hypopyon, or fibrin formation between the four groups. However, epithelial defect, stromal edema, conjunctival injection, and chemosis were significantly higher in the 5 % and 10 % povidone iodine groups when compared to the cefazolin and vancomycin groups. Thinning was more common in the cefazolin group. There was one sealed corneal perforation in the cefazolin group at the beginning, and at day 6, one perforation in the cefazolin group and one perforation in the 10 % povidone iodine group also developed.
Conclusions: Cefazolin and vancomycin had a superior clinical effect on the staphylococcal corneal ulcers in this study. 5 % and 10 % povidone iodine was toxic to the corneal epithelium. Thinning and perforation was more common with cefazolin.

Implication for health policy/practice/research/medical education:
Lower effect of povidone iodine may be the result of the lack of deep penetration of this drug into the corneal stroma, but other factors may be involved.
Please cite this paper as:
Feghhi M, Amin M, Zamani M, Najdi D. Comparison of Vancomycin and Cefazolin Therapeutic Effect With Povidone Iodine on Corneal Ulcer in Rabbits. Jundishapur J Microbiol. 2012;5(3):491-6. DOI: 10.5812/jjm.4129

Keywords

Fulltext

Full text is available in PDF

Sub-Conjunctival Injection of Antibiotics vs. Povidone-Iodine Drop on Bacterial Colonies in Phacoemulsification Cataract Surgery

Mahamoudreza Panahibazaz,

Mojataba Moosavian,

Gholamreza Khataminia,

Mostafa Feghhi,

Farsim Yazdi,

Effat Abbasi Montazeri

Panahibazaz M, Moosavian M, Khataminia G, Feghhi M, Yazdi F, et al. Sub-Conjunctival Injection of Antibiotics vs. Povidone-Iodine Drop on Bacterial Colonies in Phacoemulsification Cataract Surgery. Jundishapur J Microbiol. 2014;7(9):e13108. doi: https://doi.org/10.5812/jjm.13108

20

Nov

2010

Formulation and Clinical Evaluation of Povidone-Iodine Ophthalmic Drop

Rahim Bahri Najaf,

Soleyman Mohammadi Samani,

Nahid Pishva,

Fateme Moheimani

Bahri Najaf R, Mohammadi Samani S, Pishva N, Moheimani F. Formulation and Clinical Evaluation of Povidone-Iodine Ophthalmic Drop. Iran J Pharm Res. 2022;2(3):e127631. doi: https://doi.org/10.22037/ijpr.2010.44

1

Oct

2008

Comparative Study of Therapeutic Effects of Honey and Povidone Iodine in Surgical Wound Healing in Rabbit

N Sakhavar,

N Khadem

Sakhavar N, Khadem N. Comparative Study of Therapeutic Effects of Honey and Povidone Iodine in Surgical Wound Healing in Rabbit. Shiraz E-Med J. 2008;9(4):. doi:

31

Jan

2019

Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study

Mohammad Zavarshani,

Malahat Ahmadi,

Habib Dastmalchi Saei,

Ali Asghar Tehrani,

Bahram Dalir Naghadeh

Zavarshani M, Ahmadi M, Dastmalchi Saei H, Tehrani AA, Dalir Naghadeh B. Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study. Iran J Pharm Res. 2019;18(1):e126121. doi: https://doi.org/10.22037/ijpr.2019.2328

5

Oct

2025

Incidence of Acute Post-cataract Surgery Endophthalmitis in Two Major Referral Centers in Iran and the Prophylactic Effect of Perioperative Vancomycin: An Observational Retrospective Study

Masood Bagheri,

Farid Daneshgar,

Amir Eftekhari Milani,

Azadeh Mohammadipoor,

Peyman Ghodraty,

Salar Abed Nikmanesh

Bagheri M, Daneshgar F, Eftekhari Milani A, Mohammadipoor A, Ghodraty P, et al. Incidence of Acute Post-cataract Surgery Endophthalmitis in Two Major Referral Centers in Iran and the Prophylactic Effect of Perioperative Vancomycin: An Observational Retrospective Study. Shiraz E-Med J. 2025;26(12):e163872. doi: https://doi.org/10.5812/semj-163872

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 4
Last Update: 1 week ago
Scopus by Title: 4
Last Update: 1 week ago
Scopus by Title (Ref): 4
Last Update: 1 week ago
CrossRef: 3
Last Update: 1 day ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Mostafa Feghhi:[PubMed][Scholar]
Mansour Amin:[PubMed][Scholar]
Mitra Zamani:[PubMed][Scholar]
Danial Najdi:[PubMed][Scholar]

Ahvaz Jundishapur University of Medical Sciences

Outlines

Comparison of Vancomycin and Cefazolin Therapeutic Effect with Povidone Iodine on Corneal Ulcer in Rabbits

Abstract

Fulltext

Similar Articles

Sub-Conjunctival Injection of Antibiotics vs. Povidone-Iodine Drop on Bacterial Colonies in Phacoemulsification Cataract Surgery

Formulation and Clinical Evaluation of Povidone-Iodine Ophthalmic Drop

Comparative Study of Therapeutic Effects of Honey and Povidone Iodine in Surgical Wound Healing in Rabbit

Comparison Therapeutic Effects of Ciprofloxacin, Silver Nanoparticles and Their Combination in the Treatment of Pseudomonas keratitis in Rabbit: An Experimental Study

Incidence of Acute Post-cataract Surgery Endophthalmitis in Two Major Referral Centers in Iran and the Prophylactic Effect of Perioperative Vancomycin: An Observational Retrospective Study

Crossmark

Checking

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 day ago