Comparing Poisonous Effects of Thioacetamide and Silver Nanoparticles on Enzymic Changes and Liver Tissue in Mice

Background: Nanoparticles are small particles which can destroy many diseases resulting from microorganisms. Due to very small size, these particles can penetrate various tissues easily like liver and many side effects. This study has compared poisonous effects of thioacetamide with silver nanoparticles on amino transferase enzymes and liver tissue in male mice.

Materials and Methods: In this study, mice were divided to four groups. First group or control was received food and water, second group received thioacetamide 50 mg/kg, third group received 3000 ppm silver nanoparticles and fourth group received a compound of silver nanoparticles 3000 ppm and thioacetamide (50 mg/kg). Then, blood from mice hearts was collected and liver tissue was separated for measuring, SGPT and SGOT enzymes, and also for tissue studies.

Results: Injection thioacetamide increased SGOT and SGPT enzymes in second group more significantly than group. However, nanosilver injection only increased SGPT enzyme significantly (p=0.02).

Conclusion: According to the results of this study, silver nanoparticles and thioacetamide can damage liver cells. But destruction of hepatocytes resulting from oxidative pressure of combination silver nanoparticles and thioacetamide was more than the other groups.