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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency
Authors
1Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
2Department of Psychiatry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
3Department of Physiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Endocrine Research Center, Shahid Beheshti University, Tehran, Iran
*Corresponding Author: Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran Email: asaee_ra@yahoo.com
Published online:Nov 05, 2012
Article type:Research Article
Received:Nov 02, 2011
Accepted:Jan 12, 2012
How to Cite:Assaei R, Nazari H, Pajouhi N, Zahedi-Asl S. Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency. Zahedan J Res Med Sci. 2013;15(4):e93008. doi:
Abstract
Background : Drug abuse is associated with numerous complications including hormonal disorders of hypothalamic-pituitary-gonadal axis and spermatogenic disorders. We have compared the hormone concentration of pituitary-gonadal axis and the semen analysis in opioid-dependent and non-opioid-dependent men.
Materials and Methods : In this case-control study, serum concentration of pituitary- gonadal axis hormones and semen analysis in 48 opioid-dependent men as eligible to participate in the study were compared with those in 12 non-dependent men.
Results : Free testosterone concentration in all test groups was significantly less than that in control group. Furthermore, the concentration of Dihydrotestosterone (DHT) and Dehydroepiandrosterone Sulfate (DHEAS) in all test groups except those addicted to heroin was less than in those in control group. Concentrations of LH, FSH, prolactin, SHBG, progesterone and estradiol, normal and abnormal sperm count in test groups were significantly different from control group. However, in all test groups, sperm motility rate was less than control group. No significant relationship was found between the concentration of sex hormones and the status of sperms motility.
Conclusion : Chronic use of opioids will affect testosterone hormone and sperm, and it will cause hypogonadism and impairment of sperm motility.
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References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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