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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
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Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat
Author(s):
Fateme Arbabi-Kalati1,*, Mehran Mesgari-Abbasi2, Mojgan Nasirinasab3, Maryam Sohrabi4, Leila Roshangar5, Jafar Soleimanirad5, Amir A. Khaki5, Yousof Doustar6, Yousof Javadzade71Department of Oral Medicine, Genetics of Non Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Dentist, Zahedan University of Medical Sciences, Zahedan, Iran
4Department of Anatomical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
5Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
6Department of Pathology, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
7Department of Pharmacology, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Department of Oral Medicine, Genetics of Non Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran Email: [email protected]
Published online:Jan 17, 2011
Article type:Research Article
Received:May 05, 2010
Accepted:Jun 15, 2010
How to Cite:Arbabi-Kalati F, Mesgari-Abbasi M, Nasirinasab M, Sohrabi M, Roshangar L, et al. Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat. Zahedan J Res Med Sci. 2013;15(1):e93130. doi:
Abstract
Background : Cyclo-oxygenase-2 (COX-2) specific inhibitors were examined for predication or treatment of different tumors and it is indicated that COX-2 specific inhibitors play an important regulatory role in apoptosis of tumoral tissues. Therefore, the present study was designed in order to examine the preventive effects of a COX-2 specific inhibitor called celecoxib on 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma on rat.
Materials and Methods : In this experimental study, 30 Sprague Dawley rats (with the age of 3- 3.5 months) were selected and divided into three groups. In order to induce lingual carcinoma, 4NQO powder was prepared 3 times a week for each cage. In this study, celecoxib power was mixed with a basic food (basal diet) in order to examine the systematic effect. Tongue samples were sent to laboratory for immunohistochemical (IHC) staining and histological examination.
Results : Based on morphological criteria and the ratio of apoptosis to cell proliferation, the prevalence of tongue precancerous lesions was reduced significantly by celecoxib.
Conclusion : Celecoxib systematic has inhibitory effects on the 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma of tongue. The effect of celecoxib is probably via suppression of cell proliferation and induction of apoptosis.
References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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Search Relations
Author(s):
- Fateme Arbabi-Kalati:[PubMed][Scholar]
- Mehran Mesgari-Abbasi:[PubMed][Scholar]
- Mojgan Nasirinasab:[PubMed][Scholar]
- Maryam Sohrabi:[PubMed][Scholar]
- Leila Roshangar:[PubMed][Scholar]
- Jafar Soleimanirad:[PubMed][Scholar]
- Amir A. Khaki:[PubMed][Scholar]
- Yousof Doustar:[PubMed][Scholar]
- Yousof Javadzade:[PubMed][Scholar]
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