Fulltext
The full text of this article is available on the PDF file.
Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Anti-leishmanial effect of nanosilver solutions on Leishmania tropica promastigotes by in-vitro assay
Authors
1MPH student &DVM, Dermatology & Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
2Proffesor of Parasitology, Dermatology & Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
3PhD student of Parasitology, School of Hygiene, Tehran University of Medical Sciences, Tehran, Iran.
4Instructor of Parasitology, Dermatology & Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
5Instructor of Medical Entomology, Dermatology & Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
*Corresponding Author: Proffesor of Parasitology, Dermatology & Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran. Email: iraj.sharifi@yahoo.com
Published online:May 19, 2011
Article type:Research Article
Received:Jul 04, 2011
Accepted:Apr 10, 2011
How to Cite:Khosravi A, Sharifi I, Barati M, Zarean M, Hakimi-Parizi M. Anti-leishmanial effect of nanosilver solutions on Leishmania tropica promastigotes by in-vitro assay. Zahedan J Res Med Sci. 2011;13(7):e93813. doi:
Abstract
Background: At present, nanosilver particles are used against a broad spectrum of microbial agents. The objective of this study was to evaluate the anti-leishmanial effect of nanosilver solutions on L. tropica promastigotes as compared with the trivalent antimony compound by colorimetric assay.
Materials and Method: Promastigots of L. tropica were cultured in RPMI-1640 consisting of 10% fetal calf serum (FCS) and antibiotics at 24±10C. The effect of various concentrations of nanosilver solutions was evaluated in comparison with tartar emetic. Optical density as the result of tetrazolium salts (MTT) reduction by the promastigotes into a formozan product and it was calculated by Elisa reader and IC50 (50% inhibitory concentration), subsequently.
Results: Both, nanosilver particles and tartar emetic inhibited the growth of L. tropica promastigotes. The IC50 for nanosilver solutions was significantly higher (14.9 µg/mL) than the corresponding value (5.3 µg/mL) for the control drug (p<0.001).
Conclusion: Since nanosilver particles showed an effective anti-leishmanial activity, further works are required to evaluate the effect in animal model or human volunteers.
Highlights
References
- 1.The References of this article are available on the PDF file.
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
3
Oct
2018
In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis
Tahereh Zadeh Mehrizi,
Nariman Mosaffa,
Mostafa Haji Molla Hoseini&lrm;,
Mehdi Shafiee Ardestani,
Ali Khamesipour,
Hasan Ebrahimi Shahmabadi
,et al.Zadeh Mehrizi T, Mosaffa N, Haji Molla Hoseini&lrm; M, Shafiee Ardestani M, Khamesipour A, et al. In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis. Arch Clin Infect Dis. 2018;13(5):e80314. doi: https://doi.org/10.5812/archcid.80314
1
Sep
2014
Anti Leishmanial Effect of Zinc Sulphate on the Viability of Leishmania tropica and L. major Promastigotes
Ali Fattahi Bafghi,
Mohammad Noorbala,
Mohammad Taghi Noorbala,
Mahdi Aghabagheri
Fattahi Bafghi A, Noorbala M, Taghi Noorbala M, Aghabagheri M. Anti Leishmanial Effect of Zinc Sulphate on the Viability of Leishmania tropica and L. major Promastigotes. Jundishapur J Microbiol. 2014;7(9):e11192. doi: https://doi.org/10.5812/jjm.11192
24
Dec
2018
In Vitro Effects of Ketotifen and Cromolyn Sodium on Promastigotes and Amastigotes of Leishmania major
Lima Asgharpour Sarouey,
Khadijeh Khanaliha,
Parvaneh Rahimi-Moghaddam,
Samaneh Khorrami,
Mohammad Saaid Dayer,
Fatemeh Tabatabaie
Asgharpour Sarouey L, Khanaliha K, Rahimi-Moghaddam P, Khorrami S, Dayer MS, et al. In Vitro Effects of Ketotifen and Cromolyn Sodium on Promastigotes and Amastigotes of Leishmania major. Jundishapur J Microbiol. 2019;12(1):e82389. doi: https://doi.org/10.5812/jjm.82389
28
Oct
2019
Assessment of the Effect of Lactoferrin on Promastigote and Amastigote Forms of Leishmania major In Vitro
Yasaman Gholamipour Baroogh,
Khadijeh Khanaliha,
Fatemeh Maleki,
Hossein Torkashvand,
Fatemeh Tabatabaie
Gholamipour Baroogh Y, Khanaliha K, Maleki F, Torkashvand H, Tabatabaie F. Assessment of the Effect of Lactoferrin on Promastigote and Amastigote Forms of Leishmania major In Vitro. Jundishapur J Microbiol. 2019;12(9):e95865. doi: https://doi.org/10.5812/jjm.95865
6
Apr
2020
Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo
Payman Tavakoli,
Minoo Shaddel,
Mohammad Yakhchali,
Nasrin Raoufi,
Hamid Shamsi,
Mani Dastgheib
Tavakoli P, Shaddel M, Yakhchali M, Raoufi N, Shamsi H, et al. Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo. Ann Mil Health Sci Res. 2020;18(1):e100630. doi: https://doi.org/10.5812/amh.100630
Cited by
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 0
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 11 hours ago
- OpenAlex: 0
Last Update: 1 day ago
- OpenCitations: 0
Last Update: 4 days ago
Comments
Number of Comments:0