The effect of Indomethacin suppositories on pain relief after cesarean delivery with general anesthesia

Background: All patients be experienced a feeling of pain after surgeries. We studied the
sedative effect of rectal Indomethacin (R.I) after cesarean section (C/S) with general anesthesia
and compared the severity of pain and frequency of narcotic use in case (use of R.I) and control
group (UN use of R.I).
Methods and Materials: In a clinical trial case - control study (2002-2003) 104 women with a
C/S under general anesthesia in Zahedan Ghods hospital were studied. Patients randomly
divided in two groups. 52 patients in case group received 100 mg Indomethacin rectaly every 12
hours. 52 patients in control group don't received Indomethacin.
All patients visited carefully before C/S and preterm labor (<37 week of gestational age),
history of previous C/S, asthma, peptic ulcer and kidney disease were excluded from this study.
Induction of anesthesia was similar in all patients with 5 mg/iv morphine and 1-2mg/IV Fentanil
general. Every 6 hours after C/S patients were fallowed and compared for frequency of sever
pain and narcotic injection, the time of oral feeding and ambulation were recorded and analysis
were done by SPSS.
Results: According to this study there was significant difference between feeling of severe
pain and the need for sedative narcotic drugs in case and control groups after C/S (P<0.01). In
case group patient’s ambulation and regular diet is shorter than control group.
Conclusions: It seems that rectal Indomethacin after C/S reduces the feeling of severs pain
and narcotic use to six times, and reduces 6-12 time of the ambulation and eating regular diet.
That can cause a short recovery period after C/S.