Archives of Clinical Infectious Diseases
Mahrokhsar Fotouhi1, Gita Eslami2,*, Habibolah Peirovi3, Mohammad Hashemibahramani4, Masoumeh Douraghi2, Elahe Ahmadzadeh3Totally, 59 specimens of liver were collected from two health care centers affiliated to Shahid Beheshti University of Medical Sciences, including 22 specimens of hepatocellular carcinoma, 18 specimens of cirrhosis and 19 normal specimens of liver. Polymerase chain reaction was used to determine the presence of H. pylori in liver samples using H. pylori gene-specific primers.
16srRNA of Helicobacter genus were found in 31.8% of hepatocellular carcinoma and 16.7% of cirrhotic specimens, however, we could not find this gene in normal samples. Meanwhile, the presence of ureC and cagA genes specific for H. pylori were investigated in positive specimens to confirm the H. pylori infection, however, these genes
Helicobacter infection exists in liver of patients with hepatocellular carcinoma. However, further studies are necessary to confirm this association.
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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