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Survey of Association Between Helicobacter Pylori and Hepatocellular Carcinoma in the Specimens Derived from Health Centers of Shahid Beheshti University

Author(s):
Mahrokhsar FotouhiMahrokhsar Fotouhi1, Gita EslamiGita Eslami2,*, Habibolah PeiroviHabibolah Peirovi3, Mohammad HashemibahramaniMohammad Hashemibahramani4, Masoumeh DouraghiMasoumeh Douraghi2, Elahe AhmadzadehElahe Ahmadzadeh3
1Islamic Azad University, Tonekabon Branch, Tonekabon, IR Iran
2Department of Microbiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran


Archives of Clinical Infectious Diseases:Vol. 6, issue 1; 31-4
Article type:Research Article
How to Cite:Mahrokhsar FotouhiGita EslamiHabibolah PeiroviMohammad HashemibahramaniMasoumeh DouraghiElahe Ahmadzadehet al.Survey of Association Between Helicobacter Pylori and Hepatocellular Carcinoma in the Specimens Derived from Health Centers of Shahid Beheshti University.Arch Clin Infect Dis.6(1):31-4.

Abstract

Patients and Methods:

Totally, 59 specimens of liver were collected from two health care centers affiliated to Shahid Beheshti University of Medical Sciences, including 22 specimens of hepatocellular carcinoma, 18 specimens of cirrhosis and 19 normal specimens of liver. Polymerase chain reaction was used to determine the presence of H. pylori in liver samples using H. pylori gene-specific primers.

Results:

16srRNA of Helicobacter genus were found in 31.8% of hepatocellular carcinoma and 16.7% of cirrhotic specimens, however, we could not find this gene in normal samples. Meanwhile, the presence of ureC and cagA genes specific for H. pylori were investigated in positive specimens to confirm the H. pylori infection, however, these genes

Conclusion:

Helicobacter infection exists in liver of patients with hepatocellular carcinoma. However, further studies are necessary to confirm this association.

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