Association of Interleukin‐10 Promoter Polymorphism   (‐1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India

Amar Chand‐Bhaya; Devulapalli Krishnaveni; Kondadasula Pandu‐Ranga‐Rao; Boddu Prabhakar; Abbagani Vidyasagar; Bal Murali‐Krishna; Penchikala Anita; Akka Jyothy; Pratibha Nallari; Ananthapur Venkateshwari

International Journal of Cancer Management

The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences

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Association of Interleukin‐10 Promoter Polymorphism (‐1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India

Author(s):

Amar Chand‐Bhaya¹,

Devulapalli Krishnaveni¹,

Kondadasula Pandu‐Ranga‐Rao²,

Boddu Prabhakar²,

Abbagani Vidyasagar³,

Bal Murali‐Krishna²,

Penchikala Anita²,

Akka Jyothy¹,

Pratibha Nallari⁴,

Ananthapur Venkateshwari^1,*

1Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India

2Dept. of Gastroenterology, Osmania General Hospital, Dr. NTR University of Health Sciences, Hyderabad, India

3Dept. of Gastroenterology, Gandhi Hospital, Dr. NTR University of Health Sciences, Sec-bad, India

4Dept. of Genetics, Osmania University, Hyderabad, India

International Journal of Cancer Management:Vol. 5, issue 3; e80812

Published online:Sep 30, 2012

Article type:Research Article

Received:Jan 18, 2012

Accepted:Apr 07, 2012

How to Cite:Amar Chand‐BhayaDevulapalli KrishnaveniKondadasula Pandu‐Ranga‐RaoBoddu PrabhakarAbbagani VidyasagarBal Murali‐KrishnaPenchikala AnitaAkka JyothyPratibha NallariAnanthapur Venkateshwariet al.Association of Interleukin‐10 Promoter Polymorphism (‐1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India.Int J Cancer Manag.5(3):e80812.

Abstract

Background: Gastric Cancer (GC) is one of the most commonly diagnosed malignancies. Genetic variation in genes encoding cytokines and their receptors, determine the intensity of the inflammatory response, which may contribute to individual differences in the outcome and severity of the disease. Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine inter-individual differences in IL-10 production. In the present study, we investigated the association between the IL-10 –1082 G/A polymorphism and the susceptibility to gastric cancer in a South Indian population from Andhra Pradesh.

Methods: We genotyped 100 patients diagnosed with gastric cancer and 132 healthy control subjects for -1082G/A single nucleotide polymorphism by Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) method followed by agarose gel electrophoresis.

Results: The distribution of IL-10 genotypes at -1082 G/A were GG 18 %, GA 35% and AA 47 % in gastric cancer patients and GG 31.82 %, GA 37.88 % and AA 30.3% in control subjects. The allelic frequencies of G and A were 0.355 and 0.645 in GC patients and 0.508 and 0.492 in control subjects respectively. The IL-10 -1082 A allele was associated with risk of gastric cancer (OR=1.873, 95%CI-1.285-2.73and P= 0.001048**).

Conclusion: Our study indicates that allele A of IL-10-1082 G/A polymorphism may be considered as one of the important risk factor in the etiology of gastric cancer

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