A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

A Kriplani; J Thulkar; N Agrawal; V Kulshrestha; AC Ammini; G Kumar

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

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A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

Author(s):

A Kriplani^1,*,

J Thulkar²,

N Agrawal²,

V Kulshrestha²,

AC Ammini²,

G Kumar²

1Department of Obstetrics and Gynecology, [email protected], India

2Department of Obstetrics and Gynecology, India

International Journal of Endocrinology and Metabolism:Vol. 7, issue 4; 235-241

Published online:Oct 31, 2009

Article type:Research Article

Received:Nov 14, 2008

Accepted:Nov 07, 2009

How to Cite:Kriplani A, Thulkar J, Agrawal N, Kulshrestha V, Ammini A, et al. A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne. Int J Endocrinol Metab. 2009;7(4):. doi:

Abstract

To compare the efficacy and safety of Diane 35 plus spironolactone and Diane 35 plus finasteride in the treatment of hirsutism and acne. Materials and Methods: A prospective randomized clinical trial was conducted on 120 Indian women with hirsutism. Group I patients were treated with Diane 35 plus spironolactone 100 mg daily and group II patients with Diane 35 plus finasteride 5 mg daily for 12 months. Hirsutism and acne score were graded every 3 months, for 18 months. The basal gonadotropins levels and androgens level were measured before the study. Statistical analysis was done by Student‘s t-test and repeated measure analysis followed by post hoc comparison. Results: Reduction in hirsutism and acne scores assessed every 3 months was significant (p<0.001) and similar between the two groups, indicating that if treatment was prolonged for over 12 months, reduction scores would have been better. A significant decrease in the hirsutism score of 55.3%±17.2 and 59.4%±17.5 was observed after 12 months in groups I and II respectively. Total reduction in hirsutism & acne scores of both groups was similar (P>0.05). Conclusion: Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne. For better outcomes, it is recommended that the treatment period be over 12 months.

Keywords

Hirsutism

Treatment

Diane 35

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Author(s):

A Kriplani:[PubMed][Scholar]
J Thulkar:[PubMed][Scholar]
N Agrawal:[PubMed][Scholar]
V Kulshrestha:[PubMed][Scholar]
AC Ammini:[PubMed][Scholar]
G Kumar:[PubMed][Scholar]

Research Institute for Endocrine Sciences

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A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

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