The Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events

Davood   Kazemi Saleh; Zahra   Jozanikohan

International Cardiovascular Research Journal

The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences

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The Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events

Author(s):

Davood Kazemi Saleh¹,

Zahra Jozanikohan^2,*

1Department of Cardiology, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran

2Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

International Cardiovascular Research Journal:Vol. 10, issue 1; e10308

Published online:Mar 01, 2016

Article type:Research Article

Received:Feb 11, 2015

Accepted:Jun 10, 2015

How to Cite:Kazemi Saleh D, Jozanikohan Z. The Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events.Int Cardiovasc Res J.2016;10(1):e10308.

Abstract

Background: Evidence have shown the relationship between vitamin D deficiency and cardiovascular disease.

Objectives: The present study aimed to evaluate the effect of Vitamin D deficiency treatment on the occurrence of coronary post-Percutaneous Intervention (PCI) restenosis and Major Adverse Cardiac Events (MACE).

Patients and Methods: This randomized semi-experimental non-controlled study was conducted on patients with coronary artery disease who were candidate for PCI and had referred to Baqiyatallah Hospital in a 2-month period. The patients with normal Vitamin D levels were allocated to the normal group and others were randomly assigned to treatment and non-treatment groups. All the patients were followed for 9 months. Vitamin D was measured again at the end of the 9th month and the patients were reassigned to normal and mild, moderate, and severe deficiency groups with respect to Holick classification.

Results: This study was performed on 150 subjects with the mean age of 62.46 ± 10.80 years and male/female ratio of 94/56. The results showed no significant difference among the three groups regarding age, gender, diabetes, number of cardiovascular risk factors, and other underlying risk factors for restenosis. However, a significant difference was found between the patients with normal and abnormal vitamin D levels regarding the number of stenotic vessels and number of PCIs (both P < 0.001). Nonetheless, no significant difference was found between the treated and non-treated groups regarding the number of stenotic vessels and number of PCIs (P > 0.05). At the end of the study, 32 (55.1%) out of the 58 patients (55.1%) who were deficient reached normal vitamin D levels by consuming supplements, but 7 (12%) reached normal values without using supplements (P < 0.001).

Conclusions: Treatment of vitamin D deficiency could reduce restenosis of PCI. However, this protocol is efficient for patients with moderate to severe deficiency and should be changed.

Keywords

Vitamin D

Coronary Artery Disease

Percutaneous Coronary Intervention

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Author(s):

Davood Kazemi Saleh:[PubMed][Scholar]
Zahra Jozanikohan:[PubMed][Scholar]