Abstract
Background: Cardiac troponin T (cTnT) is a sensitive and specific marker of myocardial necrosis. Prognostic significance of isolated minor elevations of cTnT is a matter of debate .The aim of this study was to assess the impact of minor elevations of cTnT on major adverse cardiac events (MACE) following percutaneous coronary intervention (PCI).
Methods: We measured cTnT levels before and after PCI and evaluated the outcomes of 112 patients with normal baseline cTnT and complex coronary artery disease who required nonemergency PCI.
Results: Elevations (more than 0.03ng/ml) in cTnT were seen in 39 patients (34.8%).The angiographic characteristics of patients with increased cTnT levels had borderline differences compared to those with normal post PCI cTnT levels. Over a mean follow-up duration of 22 months, myocardial infarction (p<0.01) and the combined rate of death, myocardial infarction and revascularization (p<0.001) were significantly higher in patients with increased levels of post PCI cTnT. Estimated 22-month MACE-free survival for patients with increased and normal cTnT levels were 66.7% and 93.2%, respectively.
Conclusion: Isolated minor elevations in cTnT after elective PCI in complex coronary lesions affect long-term prognosis regarding death, myocardial infarction and the need for repeated revascularization procedures.
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Copyright
© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.