A comparative study of sedative and anxiolytic effects of the Hypericum perforatumin and diazepam on rats

Ali  Rezaei; Kamyar Rezaei-Dorostkar; mehrdad pashazadeh; Changiz Ahmadizadeh; Behboud Jafari

Zahedan Journal of Research in Medical Sciences

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A comparative study of sedative and anxiolytic effects of the Hypericum perforatumin and diazepam on rats

Author(s):

Ali Rezaei^1,*,

Kamyar Rezaei-Dorostkar²,

mehrdad pashazadeh²,

Changiz Ahmadizadeh³,

Behboud Jafari³

1Associate Professor of Clinical Sciences, School of Veterinary, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

2Instructor of Veterinary, School of Veterinary, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

3Instructor of Microbiology, Islamic Azad University, Ahar Branch, Ahar, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 13, issue 8; e93758

Published online:May 19, 2011

Article type:Research Article

Received:Aug 26, 2010

Accepted:Sep 07, 2010

How to Cite:Ali RezaeiKamyar Rezaei-Dorostkarmehrdad pashazadehChangiz AhmadizadehBehboud JafariA comparative study of sedative and anxiolytic effects of the Hypericum perforatumin and diazepam on rats.Zahedan J Res Med Sci.13(8):e93758.

Abstract

Background: Hypericum perforatum or St. John’s wort is a plant known as a Raee flower (or Hypericum) in Persian. Hyperisin and Hyperforin are the main constituents of this plant extract that are connected to sigma opioid and GABA receptors. Its various pharmacological effects, such as analgesia, sedation, anti-spasm, anti-convulsion, anti-anxiety, and anti-bacteria have already been known.

Materials and Method: To conduct the study, the authors prepared the hydro alcohol extract taken from the aerial organ of the plant. Then, different groups of female Wistar rats, which were almost equal in age and weight, received doses of 500mg/kg and 250mg/kg of the extract, 1.2mg/kg of diazepam, and di-methyl solphoxid (as placebo) with equal volumes. The intraperitoneal injections were administered 15min before assessing the sedative/hypnotic effects (i.e. duration of the induced sleep by ketamin with a dose of 40mg/kg) and the anxiolytic effects by means of the elevated plus maze.

Results: The results showed a statistically significant increase (p= 0.00) both in the duration of the induced sleep by ketamin and in the time lapsed in the open arms in the experimental groups with high and low doses of the extract.

Conclusion: The findings suggest that the extract of Hypericum perforatum with a dose of 500mg/kg could have sedative, preanaesthetic, and anxiolytic effects.

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