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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
PROMOTION OF WOUND HEALING BY HYPERICUM PERFORATUM EXTRACT IN RABBIT
Authors
1Department of Pharmacology &Toxicology, School of Pharmacy and Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, [email protected], Iran
22Department of Pathology, School of Medicine, Ahwaz Jundishapur University of Medical Sciences, Iran
*Corresponding Author: Department of Pharmacology &Toxicology, School of Pharmacy and Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, [email protected], Iran. Email: [email protected]
Published online:Nov 30, 2007
Article type:Research Article
Received:Nov 13, 2007
Accepted:Dec 15, 2007
How to Cite:Hemmati A, Rashidi I, Jafari M. PROMOTION OF WOUND HEALING BY HYPERICUM PERFORATUM EXTRACT IN RABBIT. Jundishapur J Nat Pharm Prod. 2007;2(2):. doi:
Abstract
The aim of this work was to evaluate the effect of hydroalcoholic extract of Hypericum perforatum (St John's Wort) (SJW) on wound healing in rabbit. Wound surface area and histopathological changes following topical application of various concentartions of SJW extract (2, 5 and 10% w/w) in eucerin base were tested on full thickness excision wound in rabbit. Such effect was compared with phenytoin cream (1%) as a standard healing agent. SJW extract significantly reduced the rate of wound healing compared to no-treatment, eucerin or phenytoin treated groups. 2% SJW extract cream showed better healing profile, and the rate of healing was significantly (p<0.01) shorter than other groups. SJW showed a considerable potential for wound healing possibly by promotion of fibroblast and myofibroblasts proliferation which results in higher rate of wound closure.
Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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