Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat

Fatemeh Arbabi-Kalati; Mehran Mesgari-Abbasi; Narjes Akbari

Zahedan Journal of Research in Medical Sciences

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Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat

Author(s):

Fatemeh Arbabi-Kalati^1,*,

Mehran Mesgari-Abbasi²,

Narjes Akbari³

1Assistant Professor of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran

2Instructor of Research, Drug Applied Research Center, Tabriz University of Medical Sciences and Health Services, Tabriz, Iran.

3Resident of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 12, issue 4; e94283

Published online:Aug 19, 2010

Article type:Research Article

Received:Apr 10, 2010

Accepted:May 11, 2010

How to Cite:Fatemeh Arbabi-Kalati, Mehran Mesgari-Abbasi, Narjes Akbari, Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat.Zahedan J Res Med Sci.2010;12(4):e94283.

Abstract

Background : Oral cancer is one of the ten most frequent cancers worldwide. Reactive oxygen species (ROS), may play a key role in human cancer development. Inflammation occurs in cancers and increases oxidative stress agent COX₂ over expression in oral premalignant lesions. Several studies showed COX₂ inhibitors con improve antioxidant system. The aim of this study is the evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat.

m aterials and Method : Fifty male Sprague Dawley adult 3-3.5 months' old rats were used as animal model in this study. The tongue SCC was induced by a daily administration of 30 ppm 4-nitroquinoline 1-oxide (4-NQO), in drinking water, for 8 months. The rats in case groups received dietary or topical CCB. CCB powder was added to powdered basal diet and e ach rat received CCB with daily food. Adhesive Gels were prepared by mixing the base plasty with oral paste including two different dose of CCB. These groups include: group A» 30 ppm 4-NQO treatment group B» 30 ppm 4-NQO+dietary CCB treatment group C» 30 ppm 4-NQO+topical low dose CCB treatment group D» 30 ppm 4NQO+high dose topical CCB treatment and group E» dietary CCB as control+water.

Results : Statistical analysis showed significant differens between groups in total antioxidant, hemoglobin and nutrophilic count. �

Conclusion : Topical CCB can use as adjuvant treatment for premalignant lesions

Keywords

Oral cancer

celecoxib

antioxidant

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