Anesthesiology and Pain Medicine
Cardiovascular problems are among the most common health issues. A considerable number of cardiac patients undergo cardiac surgery, and coronary artery disease patients constitute about two-thirds of all these surgeries. The application of cardiopulmonary bypass (CBP) usually results in some untoward effects.
Studies have suggested magnesium sulfate (MgSO4) as an anti-inflammatory agent in a coronary artery bypass graft (CABG). This study aimed to assess the effect of an IV MgSO4 infusion during elective CABG (with CBP) on the blood levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?).
During a 12 month period, after review board approval and based on inclusion and exclusion criteria, 90 patients were selected and entered randomly into one of the two study groups (MgSO4 or placebo). Anesthesia, surgery and CBP were performed in exactly the same way, except for the use of MgSO4 or a placebo. Both preoperative and postoperative plasma levels of IL-6 and TNF-? were checked and compared between the two groups using an ELISA.
There was no difference found between the two groups with regard to; gender, basic variables, Ejection Fraction (EF), CBP time and aortic cross-clamp time. The preoperative levels of IL-6 and TNF-? were not different; however, their postoperative levels were significantly higher in the placebo group (P value = 0.01 for IL-6 and 0.005 for TNF-?).
This study showed that MgSO4 infusion could suppress part of the inflammatory response after CABG with CBP. This was demonstrated by decreased levels of interleukin-6 and TNF-? in postoperative serum levels in elective CABG with CBP.
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Mojtahedzadeh M, chelkeba L, Ranjvar- Shahrivar M, Najafi A, Moini M, et al. Randomized Trial of the Effect of Magnesium Sulfate Continuous Infusion on IL-6 and CRP Serum Levels Following Abdominal Aortic Aneurysm Surgery. Iran J Pharm Res. 2016;15(4):e125227. doi: https://doi.org/10.22037/ijpr.2016.1936
Etezadi F, Aklamli M, Najafi A, Khajavi M, Shariat Moharari R, et al. Evaluation of the Anti-Inflammatory Effects of Peri-Operative Infusion of Magnesium Sulfate on the Microsurgical Procedures for Intracranial Tumors. Anesth Pain Med. 2014;4(5):e22379. doi: https://doi.org/10.5812/aapm.22379
Mesbah Kiaee M, Safari S, Movaseghi GR, Mohaghegh Dolatabadi MR, Ghorbanlo M, et al. The Effect of Intravenous Magnesium Sulfate and Lidocaine in Hemodynamic Responses to Endotracheal Intubation in Elective Coronary Artery Bypass Grafting: A Randomized Controlled Clinical Trial. Anesth Pain Med. 2014;4(3):e15905. doi: https://doi.org/10.5812/aapm.15905
Jouybar R, Kabgani H, Kamalipour H, Shahbazi S, Allahyary E, et al. The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery. Int Cardiovasc Res J. 2017;6(1):e12835. doi:
Zeighami D, Akhlagh S, Khosravi M, Maghsoodi B, Azemati S, et al. The Effect of Low-Dose of Ketamine Infusion on Stress Responses in Coronary Artery Bypass Graft Surgery. Int Cardiovasc Res J. 2010;4(1):e67655. doi:
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
