International Cardiovascular Research Journal
The Official Annually Journal of Cardiovascular Research Center, Shiraz University of Medical Sciences
Outlines
The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery
Author(s):
Reza Jouybar1, Hiva Kabgani1, Hamid Kamalipour2,*, Shahrbanoo Shahbazi1, Elaheh Allahyary1, Manoocher Rasouli3, Seyd Hedayatallah Akhlagh1, Masih Shafa1, Mohammad Ghazinoor1, Mohammad Taghi Moeinvaziri1, Saeed Khademi11Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Immunology and Clinical Microbiology Research center, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: Corresponding author: Hamid Kamalipour, Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Email: [email protected]
Published online:Sep 30, 2017
Article type:Research Article
Received:May 17, 2017
Accepted:Jan 14, 2012
How to Cite:Jouybar R, Kabgani H, Kamalipour H, Shahbazi S, Allahyary E, et al. The Perioperative Effect of Ascorbic Acid on Inflammatory Response in Coronary Artery Bypass Graft Surgery; A Randomized Controlled Trial Coronary Artery Bypass Graft Surgery. Int Cardiovasc Res J. 2017;6(1):e12835. doi:
Abstract
Background: Different pharmacological agents may decrease the inflammatory response during cardiac surgery. The aim of this study was to evaluate the effect of ascorbic acid as an antioxidant on inflammatory markers (interleukins 6 and interleukin 8) released during cardiopulmonary bypass.
Method: Forty patients scheduled for elective coronary artery bypass grafting surgery, were randomly assigned to two groups. The patients in the case group were given 3 grams ascorbic acid 12-18 hours before operation and 3 grams during CPB initiation. The patients in the control group were given the same amounts of normal saline at similar times. Blood samples were collected 6 hours preoperatively and postoperative serum interleukin 6 and 8 were measured using enzyme-linked immunosorbent assay (ELISA).
Result: In both groups CPB caused an increase in IL6 and IL8 plasma concentrations compared with baseline levels, but the pattern of changes at such levels were similar in both groups after receiving ascorbic acid or placebo. Ascorbic acid did not reduce the inflammatory cytokines during CPB. Compared to the placebo, ascorbic acid had no significant effect on hemodynamic parameters such as systolic and diastolic blood pressure, heart rate, arterial blood gases, BUN, Creatinine and WBC and platelet counts.
Conclusion: Ascorbic acid has no effect on the reduction of IL6 and IL8 during CPB. Also, it causes no improvement in hemodynamics, blood gas variables, and the outcomes of patients undergoing CABG.
References
- 1.The references are available in PDF.
Copyright
© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
16
Jun
2014
Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-? in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass
Parastou Aryana,
Samira Rajaei,
Abdolhamid Bagheri,
Forouzan Karimi,
Ali Dabbagh
Aryana P, Rajaei S, Bagheri A, Karimi F, Dabbagh A. Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-? in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass. Anesth Pain Med. 2014;4(3):16316. doi: https://doi.org/10.5812/aapm.16316
30
Mar
2010
The Effect of Low-Dose of Ketamine Infusion on Stress Responses in Coronary Artery Bypass Graft Surgery
D Zeighami,
SH Akhlagh,
MB Khosravi,
B Maghsoodi,
S Azemati,
A Alipour
Zeighami D, Akhlagh S, Khosravi M, Maghsoodi B, Azemati S, et al. The Effect of Low-Dose of Ketamine Infusion on Stress Responses in Coronary Artery Bypass Graft Surgery. Int Cardiovasc Res J. 2010;4(1):e67655. doi:
12
Jan
2019
The Preventive Role of Selenium in Inflammatory Response During Coronary Artery Bypass Graft Surgery: A Randomized, Controlled Clinical Trial
Abbas Sedighinejad,
Vali Imantalab,
Ali Mirmansouri,
Ali Mohammadzadeh Jouryabi,
Bahram Naderi Nabi,
Gholamreza Kanani
,et al.Sedighinejad A, Imantalab V, Mirmansouri A, Mohammadzadeh Jouryabi A, Naderi Nabi B, et al. The Preventive Role of Selenium in Inflammatory Response During Coronary Artery Bypass Graft Surgery: A Randomized, Controlled Clinical Trial. Jundishapur J Nat Pharm Prod. 2019;14(1):e14158. doi: https://doi.org/10.5812/jjnpp.14158
4
Nov
2018
The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG
Kamal Fani,
mahdi shadnoush,
alireza jahangirifard,
Mahnoosh Foroughi,
Hossein Ali Jelveh Moghaddam,
Ali Dabbagh
Fani K, shadnoush M, jahangirifard A, Foroughi M, Jelveh Moghaddam HA, et al. The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG. J Cell Mol Anesth. 2018;3(3):e150279. doi: https://doi.org/10.22037/jcma.v3i3.19258
8
Nov
2021
The Effects of Intravenous Vitamin C on Stress Response Severity in Abdominal Hysterectomy Following Prolonged Fasting Time
Vali Imantalab,
Mandana Mansour Ghanaie,
Zahra Rafiei Sorouri,
Ali Mohammadzadeh Jouryabi,
Samaneh Ghazanfar Tehran,
Haniyeh Sadat Fayazi
,et al.Imantalab V, Mansour Ghanaie M, Rafiei Sorouri Z, Mohammadzadeh Jouryabi A, Ghazanfar Tehran S, et al. The Effects of Intravenous Vitamin C on Stress Response Severity in Abdominal Hysterectomy Following Prolonged Fasting Time. Anesth Pain Med. 2021;11(5):e119332. doi: https://doi.org/10.5812/aapm.119332
Download PDF1.11 MB
Comments
Number of Comments:0Cited by
- Scopus by DOI: 0
Last Update: 1 month ago
- Scopus by Title: 15
Last Update: 1 month ago
- Scopus by Title (Ref): 1
Last Update: 1 month ago
- CrossRef: 0
Last Update: 5 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Search Relations
Author(s):
- Reza Jouybar:[PubMed][Scholar]
- Hiva Kabgani:[PubMed][Scholar]
- Hamid Kamalipour:[PubMed][Scholar]
- Shahrbanoo Shahbazi:[PubMed][Scholar]
- Elaheh Allahyary:[PubMed][Scholar]
- Manoocher Rasouli:[PubMed][Scholar]
- Seyd Hedayatallah Akhlagh:[PubMed][Scholar]
- Masih Shafa:[PubMed][Scholar]
- Mohammad Ghazinoor:[PubMed][Scholar]
- Mohammad Taghi Moeinvaziri:[PubMed][Scholar]
- Saeed Khademi:[PubMed][Scholar]
Related Articles