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Effect of aqueous extract of Tribulus terrestris on the activity of major platelets factors and the treatment of immune thrombocyto-penic purpura
Authors
Soodabeh Aghapour
1, Ali Mostafaie2, Mehrdad Payandeh3, Kamran Mansouri2, Fariba Sohrabi4, Zahra Koolivand1, 5,*
1, Ali Mostafaie2, Mehrdad Payandeh3, Kamran Mansouri2, Fariba Sohrabi4, Zahra Koolivand1, 5,*1Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Department of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
5Department of Laboratory Sciences, School of Allied Medical Sciences, Abadan University of Medical Sciences, Abadan, Iran
*Corresponding Author: Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email:k.saye80@yahoo.com
Published online:Jul 01, 2022
Article type:Research Article
Received:Sep 28, 2021
Accepted:Nov 13, 2021
How to Cite:Aghapour S, Mostafaie A, Payandeh M, Mansouri K, Sohrabi F, et al. Effect of aqueous extract of Tribulus terrestris on the activity of major platelets factors and the treatment of immune thrombocyto-penic purpura. Compr Health Biomed Stud. 2022;1(1):e142856. doi: https://doi.org/10.22034/hmrj.2021.139993
Abstract
Introduction: Idiopathic thrombocytopenic purpura (ITP), an autoimmune disease with decreased platelet counts needs corticosteroids, intravenous immunoglobulin (IVIg), and anti-Rho in the first line and splenectomy, rituximab, and thrombopoietin in the second line of therapy. The present study reveals the application of the aqueous extract Tribulus terrestris (T. terrestris) plant in ITP treatment.
Methods: A standard aqueous extract of T. terrestris was given orally to twenty patients who were newly diagnosed with ITP in the form of 500 mg capsules (three times per day for14 days). Blood samples were taken from patients before, during, and after two weeks of treatment to count plasma Platelet Factor 4 (PF4), serotonin factor, and Von Willebrand Factor (VWF).
Results: We observed a significant increase in the platelet count among all patients, while plasma platelets and assay factor 4 decreased and VWF increased during and after treatment. Serotonin was increased on days 1 and 14 and slightly decreased once the treatment was completed.
Conclusion: Our findings suggest that T. terrestris extract can be considered an efficient alternative medicine for the treatment of ITP.
Highlights
Copyright
The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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