Journal of Kermanshah University of Medical Sciences
Peer-reviewed Medical Quarterly
e-ISSN 2588-2570
p-ISSN 2588-2562
Image Credit:J Kermanshah Univ Med Sci
Outline
Seroconversion rates after hepatitis-B vaccination in children
Authors
Mandana Afsharian1, Mohammad Ghaderi 2, Siavash Vaziri 1, Zahra Leghaei3, Keighobad Ghadiri2,*, Alireza Janbaksh1, Babak Sayad1, Feizollah Mansouri1, Kourosh Nikzad4
1Dept. Of Infectious Disease, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Dept. of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3Dept. of Health of Kermanshah Province, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Corresponding author: Keighobad Ghadiri, Dept. of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran, Tel: +98 831 4276309 Email: k_ghadiri@yahoo.com
Published online:Mar 19, 2012
Article type:Research Article
Received:Apr 11, 2011
Accepted:Jun 28, 2011
How to Cite:Afsharian M, Ghaderi M, Vaziri S, Leghaei Z, Ghadiri K, et al. Seroconversion rates after hepatitis-B vaccination in children. J Kermanshah Univ Med Sci. 2012;15(6):e78901. doi:
Abstract
Background: Hepatitis- B infection is one of the infectious diseases that transmits via blood transfiosion, blood product, injection, mother to fetus and sexual contact. Protective anti hepatitis-B titer are observed in more than 90% of healthy children. The aim of this study was to evaluate seroconversion rates in children who received routine vaccination program.
Methods: A cross sectional study was designed. 196 children who received routine hepatitis-B vaccine (at birth, 2 and 6 months old) were selected. Anti hepatitis-B titer was measured using ELISA method in 6-7 years old children. Data was analyzed using chi-square and fisher exact tests.
Results: 69 % of all participants (98 boys and 98 girls) showed protective antibody titer (71.4% in girl and 67% in boys). There was no significant correlation between sex, weight and BMI and antibody response.
Conclusion: Seroconversion rate after hepatitis–B vaccination was lower than the semilar studies. The etiology of low seroconversion rate needs to do further study in Kermanshah.
Highlights
References
- 1.The references of this article is available on PDF.
Copyright
© 2012, Journal of Kermanshah University of Medical Sciences. This open-access article is available under the Creative Commons Attribution-NonCommercial 4.0 (CC BY-NC 4.0) International License (https://creativecommons.org/licenses/by-nc/4.0/), which allows for the copying and redistribution of the material only for noncommercial purposes, provided that the original work is properly cited.
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