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Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
E-Selectin Gene Polymorphisms in Iranian Chronic Hepatitis B Patients
Author(s):
Mehrdad Hajilooi1, Amir-Houshang Mohammad Alizadeh2, Mitra Ranjbar2, Farahnaz Fallahian2, 
Seyed Moayed Alavian3,*1Department of Immunology, Hamedan University of Medical Sciences, Hamedan, IR.Iran
2Department of Gastroenterology, Shaheed Beheshti University of Medical Sciences, Tehran, IR.Iran
3Professor of Gastroenterology and Hepatology, Baqiyatallah Research Center for Gastroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, [email protected], Tehran, IR.Iran
*Corresponding Author: Professor of Gastroenterology and Hepatology, Baqiyatallah Research Center for Gastroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, [email protected], Tehran, IR.Iran. Tel: +98 21 81264070. Fax: +98 21 81264070. Email: [email protected]
Published online:Dec 31, 2007
Article type:Research Article
Received:Nov 17, 2007
Accepted:Jan 05, 2008
How to Cite:Hajilooi M, Alizadeh A, Ranjbar M, Fallahian F, Alavian S. E-Selectin Gene Polymorphisms in Iranian Chronic Hepatitis B Patients. Hepat Mon. 2007;7(4):. doi:
Abstract
Background and Aims: The aim of this study is to detect the substitutions Ser128Arg (A128C) and Leu554Phe (T554C) which responsible for E-selectin polymorphisms in patients with chronic hepatitis B and healthy controls. We investigated association of the Ser128Arg, Leu554Phe gene polymorphisms in the E-selectin gene as prototypical inflammatory molecules for susceptibility to chronic hepatitis B.
Methods: Sixty-three patients with chronic hepatitis B virus infection and 150 healthy subjects were recruited sequentially as they presented to clinic. Genomic DNA was isolated from anti-coagulated peripheral blood Buffy coat using Miller's salting-out method. The presence of the E-selectin gene polymorphisms was determined by using polymerase chain reaction amplification refractory mutation system (ARMS).
Results: Distribution of E-selectin 128 (A+C-, A+C+, A-C+) genotypes and E-selectin genotype 554 (C+T-, T+C-, C+T+) genotypes were not statistically significant different in chronic hepatitis B patients and controls by Chi-square test (P=0.41 & 0.96, respectively). Also, Two groups had not statistically significant difference in distribution of frequencies of allele 128 A by Chi-square test (P=0.41), 128 C (P=0.15), allele 554 C (P=0.85), and allele 554 T (P=0.76). Carrying allele 128 A (OR=0.587, 95% CI=0.162-2.124), 128 C (OR=1.526, 95% CI=0.849-2.745), 554 C (OR=1.245, 95% CI=0.128-12.089), and allele 554 T (OR=0.880, 95% CI=0.384-2.014) were not risk factors for susceptibility to chronic hepatitis B infection.
Conclusions: Carrying E-selectin gene polymorphisms of Ser128Arg and Leu554Phe are not risk factors for susceptibility to chronic hepatitis B.
Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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