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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Could Cancer Initiate From Bone Marrow Progenitors?
Authors
1Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia
*Corresponding Author: Corresponding author: Hmed Ben Nasr, Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia, Tel: +216-74247036, E-mail: Email: hmedbnasr@gmail.com
Published online:Jun 30, 2013
Article type:Review Article
Received:Feb 11, 2013
Accepted:Apr 09, 2013
How to Cite:Ben Nasr H, Turky Hammami S, Zeghal K. Could Cancer Initiate From Bone Marrow Progenitors?. Int J Cancer Manag. 2013;6(2):e80411. doi:
Abstract
Background: Defining cancer stem cells and their origins is of much controversy, and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein, we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an ancestral progenitor that activates a memorial program – the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. To approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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