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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Flow Cytometry Analysis of Rosa Damascena Effects on Gastric Cancer Cell Line (MKN45)
Authors
Hanieh Khatib1, Mostafa Rezaei‐Tavirani2, Saeed Heidari Keshel2, Mona Zamanian Azodi2, Roghiyeh Omidi2, Mohsen Biglarian2, Sara Sobhi3,*
1Dept. of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Sara Sobhi, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tel: +98-2122748001-2, E-mail: Email: [email protected]
Published online:Dec 30, 2013
Article type:Research Article
Received:Nov 08, 2012
Accepted:Dec 25, 2012
How to Cite:Khatib H, Rezaei‐Tavirani M, Heidari Keshel S, Zamanian Azodi M, Omidi R, et al. Flow Cytometry Analysis of Rosa Damascena Effects on Gastric Cancer Cell Line (MKN45). Int J Cancer Manag. 2013;6(Supplement):e80457. doi:
Abstract
Background: Gastric cancer is a life threatening disease. Recent studies have shown that Rosa Damascene possesses noticeable biological effects on the human body. This study, investigates the anticancer effect of Rosa Damascena on gastric cancer cell line MKN45.
Methods: Microscopic studies and MTT assay were used to examine morphological alteration, and cell survival of the cancer cells while exposing to differentvolumes of the essential oilrespectively. In addition, flow cytometry was applied to determine the cell death mechanism of the gastric cancer treated with the essential oil.
Results: The findings indicate that Rosa Damascena essential oil affects gastric cancer cells in two distinctive ways: the soluble phase increases cell viability, while the vapor phase decreases cellsurvival. Moreover, flow cytometry analysis revealed that apoptosis is the main mechanism accompanied with cell death.
Conclusion: Consequently, Rosa Damascena essential oil can be used as a potent anticancer agent in the future. However,more evaluation of this essential oil is still needed to elicit its effectivebiological activities
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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