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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
Authors
1Proteomics Research Center, Faculty of Paramedical Sciences, Shahid BeheshtiUniversity of Medical Sciences, Tehran, Iran
2Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Mostafa Rezaei Tavirani, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid BeheshtiUniversity of Medical Sciences, Tehran, Iran, Tel: +98-2122714248, E-mail: Email: rezaei.tavirani@ibb.ut.ac.ir
Published online:Dec 30, 2013
Article type:Review Article
Received:Jun 17, 2013
Accepted:Jul 02, 2013
How to Cite:Rezaei Tavirani M, Safaei A, Zali MR. The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer. Int J Cancer Manag. 2013;6(4):e80463. doi:
Abstract
Colon cancer is the cancer of the large intestine (colon), which is located in the lower part of digestive system. Colon cancer is the third most common cancer in men and the second in women worldwide. Genetic background is thought to play a role in modulating individual risks of this cancer. Many studies support an association between insulin pathway gene polymorphisms and regulation of tumor cell biology in colorectal cancer. This review examines the role of polymorphisms of insulin and obesity pathway genes (IGFs, INS, INSR, ADIPOQ, ADIPOQR, LEP and LEPR) in development of colorectal cancer.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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