Fulltext
The Full text is available in PDF.
International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Genomic and Epigenetic Instability in Colorectal Cancer
Authors
1Students' Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Mostafa Rezaei Tavirani, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Tel: +98-2122714248, E-mail: Email: [email protected]
Published online:Dec 30, 2013
Article type:Review Article
Received:Oct 19, 2012
Accepted:Dec 24, 2012
How to Cite:Safaei A, Sobhi S, Rezaei Tavirani M, Zali MR. Genomic and Epigenetic Instability in Colorectal Cancer. Int J Cancer Manag. 2013;6(Supplement):e80473. doi:
Abstract
Colorectal Cancer (CRC) is the third most common cancer in men and the second most common cancer in women worldwide. Both genetic and epigenetic alterations are common in CRC and are the driving force of tumorigenesis. Chromosomal instability, microsatellite instability and CpG island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. Chromosomal instability pathway consists of activation of proto-oncogenes and inactivation of tumor suppression genes and Loss of Heterozogosity (LOH). In this review, we discuss genetic and epigenetic phenomena that can be suggested as biomarkers in colorectal cancer
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
25
Sep
2013
Microsatellite Instability Markers Status in Colorectal Cancer
Giti Esmailnia,
Mahdi Montazer Haghighi,
Gholamreza Javadi,
Kazem Parivar,
Mohammadreza Zali
Esmailnia G, Montazer Haghighi M, Javadi G, Parivar K, Zali M. Microsatellite Instability Markers Status in Colorectal Cancer. Zahedan J Res Med Sci. 2014;16(12):26-30. doi:
20
Jul
2014
Colorectal Carcinomas, a Consideration on MUTYH-Associated Polyposis
Tayebeh Hamzehloei,
Mahdieh Davoodnejad Dehsorkhi
Hamzehloei T, Davoodnejad Dehsorkhi M. Colorectal Carcinomas, a Consideration on MUTYH-Associated Polyposis. Shiraz E-Med J. 2014;15(3):e21868. doi: https://doi.org/10.17795/semj21868
31
Dec
2017
The Prevalence and Associated Factors of Microsatellite Instability in Ovarian Epithelial Cancers Detected by Molecular Genetic Studies in a Sample of Iranian Women
Reza Shahsiah,
Samaneh Salarvand,
Rosa Miri,
Reza Ghalehtaki,
Nasser Rakhshani
Shahsiah R, Salarvand S, Miri R, Ghalehtaki R, Rakhshani N. The Prevalence and Associated Factors of Microsatellite Instability in Ovarian Epithelial Cancers Detected by Molecular Genetic Studies in a Sample of Iranian Women. Int J Cancer Manag. 2017;10(12):e11599. doi: https://doi.org/10.5812/ijcm.11599
12
May
2011
Epigenetic mechanisms in the initiation of hematological malignancies
Ali Maleki,
Saied Kaviani,
Mehrdad Noruzinia,
Majid Farshdusti-Hagh,
Zeinab Kaviani,
kamran mansouri
Maleki A, Kaviani S, Noruzinia M, Farshdusti-Hagh M, Kaviani Z, et al. Epigenetic mechanisms in the initiation of hematological malignancies. Zahedan J Res Med Sci. 2011;13(5):e93905. doi:
7
May
2018
Epigenetic Alterations and Cancer
Mojgan Naghitorabi
Naghitorabi M. Epigenetic Alterations and Cancer. Jundishapur J Nat Pharm Prod. 2018;13(2):e69295. doi: https://doi.org/10.5812/jjnpp.69295
Cited by
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 5
Last Update: 3 weeks ago
- Scopus by Title (Ref): 5
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 5 days ago
Comments
Number of Comments:0