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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Severe Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma
Authors
1Dept. of Pediatric Neurology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Oncopathology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3Dept. of Pediatrics Nephrology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Corresponding author: Azita Tavasoli, Dept. of Pediatric Neurology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran, Tel: +98-2122222042-45, E-mail: Email: azita_tavasoli@yahoo.com
Published online:Dec 30, 2013
Article type:Case Report
Received:Jan 06, 2011
Accepted:Mar 28, 2011
How to Cite:Tavasoli A, Mehrazma M, Hooman N, Afshar Khas L. Severe Hypertension and Encephalopathy Due to Renin-Producing Hepatoblastoma. Int J Cancer Manag. 2013;6(4):e80483. doi:
Abstract
Paraneoplastic syndromes result from secretion of hormones, peptides or cytokines by tumor or immune cross-reactivity between malignant and normal tissues. These conditions are rare in children, but when the clinical presentation of patients with a tumor is unusual, these syndromes should be emphasized. Extrarenal tumors with renin-secretion are rare in children. They may be related to paraneoplastic syndromes. We report a 22-month-old infant with hepatoblastoma presented with severe hypertension and related neurologic symptoms due to high plasma renin activity. To the best of our knowledge, this is the second report of renin producing hepatoblastoma in the literature. However, due to lack of laboratory facilities such as immunohistochemical study or polyclonal antibody for human renin activity, we could not prove the secretion of renin just by tumor tissue cells, but this potentiality is very likely. Other intensive investigations did not show any other origin for rennin secretion or hypertension in this patient.
Highlights
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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