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International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study
Author(s):
Puneet Bagri1,*, Mukesh Singhal1, Daleep Singh1, Akhil Kapoor1, Shankar Lal Jakhar1, Neeti Sharma1, Surender Beniwal2, Harvindra Kumar1, Ajay Sharma1, Megh Bardia11Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India
2Medical Oncology section, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India
*Corresponding Author: Corresponding author: Puneet Bagri, Dept. of Radiation Oncology, Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner-334003, Rajasthan, India, Tel: +91-7737072711, E-mail: Email: [email protected]
Published online:Mar 31, 2014
Article type:Research Article
Received:Oct 26, 2013
Accepted:Dec 02, 2013
How to Cite:Bagri P, Singhal M, Singh D, Kapoor A, Lal Jakhar S, et al. Diagnosis of Post-Radiotherapy Local Failures in Nasopharyngeal Carcinoma: A Prospective Institutional Study. Int J Cancer Manag. 2014;7(1):e80507. doi:
Abstract
Background: This prospective study was conducted to evaluate and compare the efficacies of nasopharyngoscopy and CT scan in the diagnosis of local failure of external beam radiotherapy (EBRT) for nasopharyngeal carcinoma. Methods: Total 52 patients of histopathologically proven nasopharyngeal carcinoma treated with external beam radiotherapy (EBRT), were included in this study. For every patient computed tomography (CT), nasopharyngoscopy and nasopharyngeal biopsies were performed 3 months after completion of EBRT.
Results: Three months after completion of EBRT, 9 patients (17.3%) had evident disease on histological examination of biopsies. Nasopharyngoscopy showed 77.78% sensitivity, 93.03% specificity, 70% positive predictive value and 95.24% negative predictive value in diagnosing the residual/recurrence of tumor. There was statistically significant agreement between the endoscopic findings and the histological findings (Kappa reliability coefficient=0.562, p0.05). Conclusion: Nasopharyngoscopy should be considered the primary follow-up tool after radiotherapy of nasopharyngeal carcinoma. CT scan should be reserved for patients with histological or any symptomatic indications. Routine postnasal biopsies are not required.
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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Search Relations
Author(s):
- Puneet Bagri:[PubMed][Scholar]
- Mukesh Singhal:[PubMed][Scholar]
- Daleep Singh:[PubMed][Scholar]
- Akhil Kapoor:[PubMed][Scholar]
- Shankar Lal Jakhar:[PubMed][Scholar]
- Neeti Sharma:[PubMed][Scholar]
- Surender Beniwal:[PubMed][Scholar]
- Harvindra Kumar:[PubMed][Scholar]
- Ajay Sharma:[PubMed][Scholar]
- Megh Bardia:[PubMed][Scholar]
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