Fulltext
The Full text is available in PDF.
International Journal of Cancer Management
The Official Journal of Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences
e-ISSN 2538-497X
p-ISSN 2538-4422
Effect of Linoleic Acid of Nigella Sativa on MDA‐MB‐231 Human Breast Cancer Cells
Authors
1Dept. of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, UPM, Malaysia
2Faculty of Basic Science, Biology Dept., Alzahra University, Tehran, Iran
3Laboratory of National Product, Institute of Bioscience, University Putra, Malaysia, 43400, UPM, Malaysia
*Corresponding Author: Corresponding author: A Latiff Latiffah, Dept. of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, UPM, Malaysia, Tel: +60-389472537, E-mail: Email: latiffah@medic.upm.edu.my
Published online:Jun 30, 2011
Article type:Research Article
Received:Nov 16, 2010
Accepted:Apr 13, 2011
How to Cite:Hasanzadeh G, Latiffah AL, Hanachi P, Hj Lajis N. Effect of Linoleic Acid of Nigella Sativa on MDA‐MB‐231 Human Breast Cancer Cells. Int J Cancer Manag. 2011;4(2):e80731. doi:
Abstract
Background: Breast cancer is one of the main life-threatening diseases which a woman may face during her life. Several lifestyle factors such as weight gain, obesity, fat intake and decreased level of physical activity are associated with breast cancer risk. In vitro and vivo studies showed that, Linoleic acid (LA) is one of the main fatty acids composition of Nigella sativa. The objective was to investigate inhibitory and anti-cancer effects of Linoleic acid on the MDA-MB-231 human breast cancer cells.
Methods: The apoptosis and cytotoxic activity assay was used in order to find toxic effects and the results were supported by flow cytometry (Cell cycle analysis). The results showed the cytotoxic effect of Linoleic acid on the breast cancer cell can be considered as an anti-cancer effect of LA.
Results: According to our findings, when the concentration of lionleic acid was increased, compared with the concentrations currently being reported, it showed an anti-cancer effects. The IC50 was 84.72µl/ml. There was a significant (p<0.05) effect between the treatment groups which are more than IC 50 and the control group.
Conclusion: We came to this conclusion that Linoleic acid has an inhibitory effect on human breast cancer cell lines which can be due to its two double-bandings molecular structure.
Highlights
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
11
Oct
2017
Apoptosis Cell Death Effect of Linoleic Acid from Nigella Sativa on Human Ovary Cancer Cells through Mitochondrial Intrinsic Pathway
Yalda Shokoohinia,
Gholamreza Bahrami,
Fatemeh Taherabadi,
Fataneh Jaffari,
Leila Hosseinzadeh
Shokoohinia Y, Bahrami G, Taherabadi F, Jaffari F, Hosseinzadeh L. Apoptosis Cell Death Effect of Linoleic Acid from Nigella Sativa on Human Ovary Cancer Cells through Mitochondrial Intrinsic Pathway. J Rep Pharm Sci. 2018;7(1):e147604. doi:
18
Feb
2026
Evaluation of Cytotoxic Effects and Selectivity of Nigella sativa Extracts on MCF-7 and HDF Cell Lines
Roghayeh Daneshyar,
Mohammad Zandi,
Fariba Sharifnia,
Mohammad Reza Sanjabi,
Annahita Ghaedrahmati
Daneshyar R, Zandi M, Sharifnia F, Sanjabi MR, Ghaedrahmati A. Evaluation of Cytotoxic Effects and Selectivity of Nigella sativa Extracts on MCF-7 and HDF Cell Lines. Gene Cell Tissue. 2026;13(1):e169056. doi: https://doi.org/10.5812/gct-169056
14
May
2016
Antitumor and Antiangiogenic Effects of the Crude Oil of Nigella sativa L. in Tumor Tissues in BALB/c Mice
Sima Bahramian,
Mohammad Reza Bigdeli,
Bahram Rasoulian,
Mahdi Moridi Farimani
Bahramian S, Bigdeli MR, Rasoulian B, Moridi Farimani M. Antitumor and Antiangiogenic Effects of the Crude Oil of Nigella sativa L. in Tumor Tissues in BALB/c Mice. Zahedan J Res Med Sci. 2016;18(5):e6667. doi: https://doi.org/10.17795/zjrms.6667
15
Mar
2025
Design, Synthesis, and Evaluation of Cytotoxic Effects of Functional Fatty Acid Derivatives as Potential Antineoplastic Agents for Breast Cancer
Maryam Hosseini,
Farzad Kobarfard,
Salimeh Amidi,
Shaya Mokhtari,
Anna Sedaghat,
Soraya Shahhosseini
Hosseini M, Kobarfard F, Amidi S, Mokhtari S, Sedaghat A, et al. Design, Synthesis, and Evaluation of Cytotoxic Effects of Functional Fatty Acid Derivatives as Potential Antineoplastic Agents for Breast Cancer. Iran J Pharm Res. 2025;24(1):e159523. doi: https://doi.org/10.5812/ijpr-159523
30
Dec
2013
Flow Cytometry Analysis of Rosa Damascena Effects on Gastric Cancer Cell Line (MKN45)
Hanieh Khatib,
Mostafa Rezaei‐Tavirani,
Saeed Heidari Keshel,
Mona Zamanian Azodi,
Roghiyeh Omidi,
Mohsen Biglarian
,et al.Khatib H, Rezaei‐Tavirani M, Heidari Keshel S, Zamanian Azodi M, Omidi R, et al. Flow Cytometry Analysis of Rosa Damascena Effects on Gastric Cancer Cell Line (MKN45). Int J Cancer Manag. 2013;6(Supplement):e80457. doi:
Cited by
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 3
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 9 hours ago
- OpenAlex: 0
Last Update: 1 day ago
- OpenCitations: 0
Last Update: 4 days ago
Comments
Number of Comments:0