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International Journal of Endocrinology and Metabolism
Research Institute for Endocrine Sciences
e-ISSN 1726-9148
p-ISSN 1726-913X
Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure
Authors
1Department of Obstetrics and Gynecology,Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, I.R.Iran
2Department of Genetics, and Infertility & Reproductive Health Research Center(IRHRC), Taleghani Hospital, Shahid Beheshti University of Medical Sciences, fpoures@yahoo.com, I.R.Iran
3Research center for gastroenterology and liver diseases, Taleghani Hospital, Shahid Beheshti University of MedicalmSciences, IR.Iran
*Corresponding Author: Department of Genetics, and Infertility & Reproductive Health Research Center(IRHRC), Taleghani Hospital, Shahid Beheshti University of Medical Sciences, fpoures@yahoo.com, I.R.Iran. Email: fpoures@yahoo.com
Published online:Apr 30, 2009
Article type:Research Article
Received:Jan 01, 2008
Accepted:May 20, 2009
How to Cite:Fallahian M, Pouresmaeili F, Azizi F, Zali M, Samani E, et al. Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure. Int J Endocrinol Metab. 2009;7(2):. doi:
Abstract
Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran.
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© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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