A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

A Kriplani; J Thulkar; N Agrawal; V Kulshrestha; AC Ammini; G Kumar

International Journal of Endocrinology and Metabolism

Research Institute for Endocrine Sciences

Current Issue All Issues In Press Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

Author(s):

A Kriplani^1,*,

J Thulkar²,

N Agrawal²,

V Kulshrestha²,

AC Ammini²,

G Kumar²

1Department of Obstetrics and Gynecology, [email protected], India

2Department of Obstetrics and Gynecology, India

International Journal of Endocrinology and Metabolism:Vol. 7, issue 4; 235-241

Published online:Oct 31, 2009

Article type:Research Article

Received:Nov 14, 2008

Accepted:Nov 07, 2009

How to Cite:Kriplani A, Thulkar J, Agrawal N, Kulshrestha V, Ammini A, et al. A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne. Int J Endocrinol Metab. 2009;7(4):. doi:

Abstract

To compare the efficacy and safety of Diane 35 plus spironolactone and Diane 35 plus finasteride in the treatment of hirsutism and acne. Materials and Methods: A prospective randomized clinical trial was conducted on 120 Indian women with hirsutism. Group I patients were treated with Diane 35 plus spironolactone 100 mg daily and group II patients with Diane 35 plus finasteride 5 mg daily for 12 months. Hirsutism and acne score were graded every 3 months, for 18 months. The basal gonadotropins levels and androgens level were measured before the study. Statistical analysis was done by Student‘s t-test and repeated measure analysis followed by post hoc comparison. Results: Reduction in hirsutism and acne scores assessed every 3 months was significant (p<0.001) and similar between the two groups, indicating that if treatment was prolonged for over 12 months, reduction scores would have been better. A significant decrease in the hirsutism score of 55.3%±17.2 and 59.4%±17.5 was observed after 12 months in groups I and II respectively. Total reduction in hirsutism & acne scores of both groups was similar (P>0.05). Conclusion: Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne. For better outcomes, it is recommended that the treatment period be over 12 months.

Keywords

Hirsutism

Treatment

Diane 35

Full Text

Full text is available in PDF

Oral Pulse Betamethasone, Methotrexate, and Combination Therapy to Treat Severe Alopecia Areata: A Randomized, Double-blind, Placebo-controlled, Clinical Trial

Ali Asilian,

Farahnaz Fatemi,

Zakiye Ganjei,

Amir Hossein Siadat,

Fatemeh Mohaghegh,

Mansour Siavash

Asilian A, Fatemi F, Ganjei Z, Siadat AH, Mohaghegh F, et al. Oral Pulse Betamethasone, Methotrexate, and Combination Therapy to Treat Severe Alopecia Areata: A Randomized, Double-blind, Placebo-controlled, Clinical Trial. Iran J Pharm Res. 2021;20(1):e124354. doi: https://doi.org/10.22037/ijpr.2020.113868.14536

17

Dec

2021

A Randomized, Double-blind Controlled Clinical Study to Evaluate the Efficacy and Safety of Minoxidil Topical 2% Nanosuspension with Aqueous Base in the Treatment of Androgenetic Alopecia Areata

Shahla Mirzaeei,

Ashkan Barfar,

Saba Mehrandish,

Ali Ebrahimi

Mirzaeei S, Barfar A, Mehrandish S, Ebrahimi A. A Randomized, Double-blind Controlled Clinical Study to Evaluate the Efficacy and Safety of Minoxidil Topical 2% Nanosuspension with Aqueous Base in the Treatment of Androgenetic Alopecia Areata. J Rep Pharm Sci. 2021;10(2):e146965. doi: https://doi.org/10.4103/jrptps.JRPTPS_25_21

6

Nov

2013

Comparison the effect of manhae supplement with hormone therapy on frequency and intensity of hot flashes in postmenopausal women

30

Jul

2007

Comparing the Efficacy of add-on Nortryptiline With Triiodothyronine in the Management of Citalopram-Resistant Depression

Naghmeh Mokhber,

Ali Talaei

Mokhber N, Talaei A. Comparing the Efficacy of add-on Nortryptiline With Triiodothyronine in the Management of Citalopram-Resistant Depression. Iran J Psychiatry Behav Sci. 2007;1(2):. doi:

30

Sep

2004

Comparison of acid salisylic 2% and betamethasone with topical fish oil in recovery of psoriasis signs

R Ghaderi,

F Madar Shahian

Ghaderi R, Madar Shahian F. Comparison of acid salisylic 2% and betamethasone with topical fish oil in recovery of psoriasis signs. J Inflamm Dis. 2024;8(2):e155043. doi:

Import into EndNote Import into BibTex

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 1 week ago
Scopus by Title: 0
Last Update: 1 week ago
Scopus by Title (Ref): 0
Last Update: 1 week ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

A Kriplani:[PubMed][Scholar]
J Thulkar:[PubMed][Scholar]
N Agrawal:[PubMed][Scholar]
V Kulshrestha:[PubMed][Scholar]
AC Ammini:[PubMed][Scholar]
G Kumar:[PubMed][Scholar]

Research Institute for Endocrine Sciences

Outlines

A Comparative Study of Diane?35 plus Spironolactone and Diane ?35 Plus Finasteride in Cases of Hirsutism and Acne

Abstract

Full Text

Similar Articles

Oral Pulse Betamethasone, Methotrexate, and Combination Therapy to Treat Severe Alopecia Areata: A Randomized, Double-blind, Placebo-controlled, Clinical Trial

A Randomized, Double-blind Controlled Clinical Study to Evaluate the Efficacy and Safety of Minoxidil Topical 2% Nanosuspension with Aqueous Base in the Treatment of Androgenetic Alopecia Areata

Comparison the effect of manhae supplement with hormone therapy on frequency and intensity of hot flashes in postmenopausal women

Comparing the Efficacy of add-on Nortryptiline With Triiodothyronine in the Management of Citalopram-Resistant Depression

Comparison of acid salisylic 2% and betamethasone with topical fish oil in recovery of psoriasis signs

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 1 week ago

Last Update: 3 days ago