Prevalence of Celiac Disease in Children with Idiopathic Dilated Cardiomyopathy

Mozhgan  Zahmatkeshan; Mahsa  Fallahpoor; Hamid  Amoozgar

Innovative Journal of Pediatrics

The Scientific Journal of Growth & Development Research Center

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Prevalence of Celiac Disease in Children with Idiopathic Dilated Cardiomyopathy

Author(s):

Mozhgan Zahmatkeshan^1,*,

Mahsa Fallahpoor²,

Hamid Amoozgar³

Innovative Journal of Pediatrics:Vol. 24, issue 5

Published online:Jul 05, 2014

Article type:Research Article

Received:Oct 24, 2013

Accepted:May 14, 2014

How to Cite: Zahmatkeshan M, Fallahpoor M, Amoozgar H. Prevalence of Celiac Disease in Children with Idiopathic Dilated Cardiomyopathy. Inn J Pediatr. 2014;24(5):. doi:

Abstract

Objective: This study aimed to evaluate the prevalence of celiac disease (CD) in the patients with dilated cardiomyopathy (DCM). Simultaneous presentation of these two diseases has been recently reported in some studies; however, few researches have been done on children. The sooner CD is diagnosed, the better the prognosis will be, especially in the patients with a chronic disease like DCM. Methods: In this study, 82 cases were screened for CD by measuring the level of anti-body against transglutaminase (anti tTG). These cases included 41 patients with DCM labeled according to clinical evaluation and echocardiography and 41 healthy children who had been referred for routine checkup. All the patients were between 1 and 18 years old. The expired patients and those with previous diagnosis of CD were excluded from the study. Besides, the patients with positive antibody results underwent intestinal biopsy to match the serology findings with histopathology of CD in the intestine. Finally, the data were analyzed by the SPSS statistical software (v. 16) and through t-test and Pearson correlation coefficient. Findings: According to the findings, 1/41 (2.5%) DCM cases had positive tTG antibody level and negative intestinal biopsy which is classified as potential CD in the children with DCM. In addition, 7/41 (17%) patients had borderline anti body level. A direct correlation was observed between age and anti tTG level. Conclusion: It is beneficial to assess CD in DCM children with unknown cause.

Keywords

Celiac Disease

Dilated Cardiomyopathy

Children

Heart

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Author(s):

Mozhgan Zahmatkeshan:[PubMed][Scholar]
Mahsa Fallahpoor:[PubMed][Scholar]
Hamid Amoozgar:[PubMed][Scholar]

The Scientific Journal of Growth & Development Research Center

Outlines

Prevalence of Celiac Disease in Children with Idiopathic Dilated Cardiomyopathy

Abstract

Fulltext

References

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 1 month ago

Last Update: 6 days ago