Logo
homeHome
toggle_offCompany ProfilegroupsBoards & Staffsworkspace_premiumMemberships & PartnersschoolAcademy of Journalismperson_addCareerslinkBlog(EN)emailContact Us
list_altOur JournalslightbulbInstruction for AuthorsbookmarkBrieflands PolicieshandshakePublish My Researchplay_circleJournal Management Systemcredit_cardArticle Processing Chargeszoom_inOpen Peer ReviewimagePublishing Services
menu_bookPublish My Book

Koomesh

Journal of Semnan University of Medical Sciences

homeHome
listAll Issuesplay_arrowIn Presscheck_circleAccepted ManuscriptssearchSearch
lightbulbInstructions
infoJournal InformationgroupsEditors & BoardspublicIndexing and Listing Sourcesquery_statsJournal Metricszoom_inOpen Peer Review (OPR)balancePublication Ethics and Publication Malpractice Statementassignment_indReviewer and AE Registration FormchatSupportphone_in_talkContact Us
euroAPC
Authors GuideSubmit Manuscript
koomesh

Image Credit:koomesh

Outlines

https://doi.org/10.69107/koomesh-157890

Examination of the Role of Potassium Channels in the Relaxant Effects of Quercetin on Intestinal Smooth Muscle Contractions

Author(s):
Hasan SadraeiHasan Sadraei1, Faezeh BahramiFaezeh Bahrami2, Maedeh GhasemiMaedeh GhasemiMaedeh Ghasemi ORCID3,*
1Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Koomesh:Vol. 27, issue 6; e157890
Published online:Oct 27, 2025
Article type:Research Article
How to Cite:Sadraei H, Bahrami F, Ghasemi M. Examination of the Role of Potassium Channels in the Relaxant Effects of Quercetin on Intestinal Smooth Muscle Contractions. koomesh. 2025;27(6):e157890. doi: https://doi.org/10.69107/koomesh-157890

Abstract

Keywords
Quercetin
Relaxation
Potassium Channels
Ileum

References

  • 1.
    1. Yao Y, Habib M, Bajwa HF, Qureshi A, Fareed R, Altaf R, et al. Herbal therapies in gastrointestinal and hepatic disorders: An evidence-based clinical review. Front Pharmacol. 2022;13:962095. [PubMed ID:36278240]. [PubMed Central ID:PMC9581220]. https://doi.org/10.3389/fphar.2022.962095.
  • 2.
    2. Uyanga VA, Amevor FK, Liu M, Cui Z, Zhao X, Lin H. Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review. Nutrients. 2021;13(11). [PubMed ID:34836037]. [PubMed Central ID:PMC8621968]. https://doi.org/10.3390/nu13113782.
  • 3.
    3. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45(11):2179-205. [PubMed ID:17698276]. https://doi.org/10.1016/j.fct.2007.05.015.
  • 4.
    4. Roghani M, BalochMojarad T. [Endothelium-dependent and–independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats]. Koomesh. 2005;6(3):223-8. Persian.
  • 5.
    5. Dadpey M, Ghorban K, Dadmanesh M. [Histopathological effects of quercetin on liver tissue damage induced by iron oxide and iron oxide nanoparticles in Wistar rats]. Koomesh. 2019;21(3):525-34. Persian.
  • 6.
    6. Mirazimi SMA, Dashti F, Tobeiha M, Shahini A, Jafari R, Khoddami M, et al. Application of Quercetin in the Treatment of Gastrointestinal Cancers. Front Pharmacol. 2022;13:860209. [PubMed ID:35462903]. [PubMed Central ID:PMC9019477]. https://doi.org/10.3389/fphar.2022.860209.
  • 7.
    7. Forney LA, Lenard NR, Stewart LK, Henagan TM. Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. Int J Mol Sci. 2018;19(3). [PubMed ID:29562620]. [PubMed Central ID:PMC5877756]. https://doi.org/10.3390/ijms19030895.
  • 8.
    8. Shams SGE, Eissa RG. Amelioration of ethanol-induced gastric ulcer in rats by quercetin: implication of Nrf2/HO1 and HMGB1/TLR4/NF-kappaB pathways. Heliyon. 2022;8(10):e11159. [PubMed ID:36311358]. [PubMed Central ID:PMC9614827]. https://doi.org/10.1016/j.heliyon.2022.e11159.
  • 9.
    9. Zhang J, Shao Z-W, Gao Y, Wang Q-Y. Influences of quercetin on contraction of small intestine smooth muscle of rabbits in vitro and its mechanism. Chinese J Appl Physiol. 2013;29(2):162-5.
  • 10.
    10. Morales MA, Lozoya X. Calcium-antagonist effects of quercetin on aortic smooth muscle. Planta Med. 1994;60(4):313-7. [PubMed ID:7938264]. https://doi.org/10.1055/s-2006-959491.
  • 11.
    11. Larson AJ, Symons JD, Jalili T. Quercetin: A Treatment for Hypertension?-A Review of Efficacy and Mechanisms. Pharmaceuticals (Basel). 2010;3(1):237-50. [PubMed ID:27713250]. [PubMed Central ID:PMC3991028]. https://doi.org/10.3390/ph3010237.
  • 12.
    12. Basir SF. Mechanism of Flavonoids Action in Smooth Muscle Relaxation. World J Pharm Pharm Sci. 2017;6:514-50. https://doi.org/10.20959/wjpps20179-9992.
  • 13.
    13. Townsend EA, Emala CW. Quercetin acutely relaxes airway smooth muscle and potentiates beta-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCbeta and PDE4. Am J Physiol Lung Cell Mol Physiol. 2013;305(5):L396-403. [PubMed ID:23873842]. [PubMed Central ID:PMC3763034]. https://doi.org/10.1152/ajplung.00125.2013.
  • 14.
    14. Modzelewska B, Drygalski K, Kleszczewski T, Chomentowski A, Korycinski K, Kielczewska A, et al. Quercetin relaxes human gastric smooth muscles directly through ATP-sensitive potassium channels and not depending on the nitric oxide pathway. Neurogastroenterol Motil. 2021;33(7):e14093. [PubMed ID:33528064]. [PubMed Central ID:PMC8365708]. https://doi.org/10.1111/nmo.14093.
  • 15.
    15. Fanning MJ, Macander P, Drzewiecki G, Middleton E. Quercetin inhibits anaphylactic contraction of guinea pig ileum smooth muscle. Int Arch Allergy Appl Immunol. 1983;71(4):371-3. [PubMed ID:6862666]. https://doi.org/10.1159/000233423.
  • 16.
    16. Rivero-Segura NA, Zepeda-Arzate EA, Castillo-Vazquez SK, Fleischmann-delaParra P, Hernandez-Pineda J, Flores-Soto E, et al. Exploring the Geroprotective Potential of Nutraceuticals. Nutrients. 2024;16(17). [PubMed ID:39275153]. [PubMed Central ID:PMC11396943]. https://doi.org/10.3390/nu16172835.
  • 17.
    17. Patel RV, Mistry BM, Shinde SK, Syed R, Singh V, Shin HS. Therapeutic potential of quercetin as a cardiovascular agent. Europ J Med Chemi. 2018;155:889-904. [PubMed ID:29966915]. https://doi.org/10.1016/j.ejmech.2018.06.053.
  • 18.
    18. Sadraei H, Tabesh S. Relaxant effect of quercetin on rabbit isolated bladder smooth muscles contractions. J Herbmed Pharmacol. 2020;10(1):61-7. https://doi.org/10.34172/jhp.2021.05.
  • 19.
    19. Luo X, Xue L, Xu H, Zhao QY, Wang Q, She YS, et al. Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle. Sci Rep. 2018;8(1):3114. [PubMed ID:29449621]. [PubMed Central ID:PMC5814568]. https://doi.org/10.1038/s41598-018-20409-x.
  • 20.
    20. Beyder A, Farrugia G. Ion channelopathies in functional GI disorders. Am J Physiol Gastrointest Liver Physiol. 2016;311(4):G581-G6. [PubMed ID:27514480]. [PubMed Central ID:PMC5142191]. https://doi.org/10.1152/ajpgi.00237.2016.
  • 21.
    21. Perrino BA. Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II. Arch Biochem Biophys. 2011;510(2):174-81. [PubMed ID:21443856]. [PubMed Central ID:PMC3134147]. https://doi.org/10.1016/j.abb.2011.03.009.
  • 22.
    22. Thorneloe KS, Nelson MT. Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Can J Physiol Pharmacol. 2005;83(3):215-42. [PubMed ID:15870837]. https://doi.org/10.1139/y05-016.
  • 23.
    23. Dabrowska A, Zajac M, Bednarczyk P, Lukasiak A. Effect of Quercetin on mitoBK(Ca) Channel and Mitochondrial Function in Human Bronchial Epithelial Cells Exposed to Particulate Matter. Int J Mol Sci. 2022;24(1). [PubMed ID:36614079]. [PubMed Central ID:PMC9820441]. https://doi.org/10.3390/ijms24010638.
  • 24.
    24. Korn SJ, Trapani JG. Potassium channels. IEEE Trans Nanobioscience. 2005;4(1):21-33. [PubMed ID:15816169]. https://doi.org/10.1109/tnb.2004.842466.
  • 25.
    25. Sadraei H, Ghasemi M, Saranji S. Evaluation of spasmolytic effects of naringenin on ileum contraction and intestinal charcoal meal transit: Involvement of ATP-sensitive K+ channels. J Herbmed Pharmacol. 2022;11(2):262-8. https://doi.org/10.34172/jhp.2022.31.
  • 26.
    26. Basile EJ, Launico MV, Sheer AJ. Physiology, Nutrient Absorption. Treasure Island (FL): StatPearls; 2025.
  • 27.
    27. Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintron M, et al. Calcium Channels in Vascular Smooth Muscle. Adv Pharmacol. 2017;78:49-87. [PubMed ID:28212803]. [PubMed Central ID:PMC5439506]. https://doi.org/10.1016/bs.apha.2016.08.002.
  • 28.
    28. Narayanan D, Adebiyi A, Jaggar JH. Inositol trisphosphate receptors in smooth muscle cells. Am J Physiol Heart Circ Physiol. 2012;302(11):H2190-210. [PubMed ID:22447942]. [PubMed Central ID:PMC3378287]. https://doi.org/10.1152/ajpheart.01146.2011.
  • 29.
    29. Ratz PH, Berg KM, Urban NH, Miner AS. Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus. Am J Physiol Cell Physiol. 2005;288(4):C769-83. [PubMed ID:15761211]. https://doi.org/10.1152/ajpcell.00529.2004.
  • 30.
    30. Tanahashi Y, Komori S, Matsuyama H, Kitazawa T, Unno T. Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice. Int J Mol Sci. 2021;22(2). [PubMed ID:33477687]. [PubMed Central ID:PMC7831928]. https://doi.org/10.3390/ijms22020926.
  • 31.
    31. Elorriaga M, Anselmi E, Hernandez JM, D'Ocon P, Ivorra D. The sources of Ca2+ for muscarinic receptor-induced contraction in the rat ileum. J Pharm Pharmacol. 1996;48(8):817-9. [PubMed ID:8887731]. https://doi.org/10.1111/j.2042-7158.1996.tb03980.x.
  • 32.
    32. Chrysafides SM, Bordes SJ, Sharma S. Physiology, Resting Potential. Treasure Island (FL): StatPearls; 2025.
  • 33.
    33. Quast U. Potassium channel openers: pharmacological and clinical aspects. Fundam Clin Pharmacol. 1992;6(7):279-93. [PubMed ID:1490649]. https://doi.org/10.1111/j.1472-8206.1992.tb00122.x.
  • 34.
    34. Rhodes HJ, Sutter MC. The Action of Diazoxide on Isolated Vascular Smooth Muscle Electrophysiology and Contraction. Canadian J Physiol Pharmacol. 1971;49(4):276-87. https://doi.org/10.1139/y71-030.
  • 35.
    35. Lee YS. Mechanism of apoptosis induced by diazoxide, a K+ channel opener, in HepG2 human hepatoma cells. Arch Pharm Res. 2004;27(3):305-13. [PubMed ID:15089036]. https://doi.org/10.1007/BF02980065.
  • 36.
    36. Meves H. The action of prostaglandins on ion channels. Curr Neuropharmacol. 2006;4(1):41-57. [PubMed ID:18615137]. [PubMed Central ID:PMC2430679]. https://doi.org/10.2174/157015906775203048.
  • 37.
    37. Yan FF, Casey J, Shyng SL. Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex. J Biol Chem. 2006;281(44):33403-13. [PubMed ID:16956886]. https://doi.org/10.1074/jbc.M605195200.
  • 38.
    38. Pompermayer K, Amaral FA, Fagundes CT, Vieira AT, Cunha FQ, Teixeira MM, et al. Effects of the treatment with glibenclamide, an ATP-sensitive potassium channel blocker, on intestinal ischemia and reperfusion injury. Eur J Pharmacol. 2007;556(1-3):215-22. [PubMed ID:17182029]. https://doi.org/10.1016/j.ejphar.2006.10.065.
  • 39.
    39. Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. Effects of tetraethylammonium-sensitive K(+) channel blockade on cholinergic and thermal sweating in endurance-trained and untrained men. Exp Physiol. 2022;107(5):441-9. [PubMed ID:35340063]. https://doi.org/10.1113/EP090251.
  • 40.
    40. Taglialatela M, Vandongen AM, Drewe JA, Joho RH, Brown AM, Kirsch GE. Patterns of internal and external tetraethylammonium block in four homologous K+ channels. Mol Pharmacol. 1991;40(2):299-307. [PubMed ID:1875913].

Similar Articles

20
Nov
2010

The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats

Mehrdad Roghani,
Tourandokht Baluchnejadmojarad,
Farshad Roghani Dehkordi

Roghani M, Baluchnejadmojarad T, Roghani Dehkordi F. The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats. Iran J Pharm Res. 2022;5(3):e128285. doi: https://doi.org/10.22037/ijpr.2010.675

8
Mar
2014

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine

Farzaneh Farajian Mashhadi,
Robert J. Naylor,
Farideh A. Javid

Farajian Mashhadi F, Naylor RJ, Javid FA. The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine. Gene Cell Tissue. 2014;1(1):e18311. doi: https://doi.org/10.17795/gct-18311

28
Feb
2016

The Effect of Ginger Hydroalcholic Extract on Rat Ileal Contraction in Vitro

Ahmad Ali Jalali-Nezhad,
Farzaneh Farajian-Mashhadi,
Gholamreza Komeili,
Farzaneh Barkhordari-Ahmadi

Jalali-Nezhad AA, Farajian-Mashhadi F, Komeili G, Barkhordari-Ahmadi F. The Effect of Ginger Hydroalcholic Extract on Rat Ileal Contraction in Vitro. Zahedan J Res Med Sci. 2016;18(2):e5984. doi: https://doi.org/10.17795/zjrms-5984

15
May
2005

Endothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats

Mehrdad Roghani,
Torandokht BalochMojarad

Roghani M, BalochMojarad T. Endothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats. koomesh. 2005;6(3):e152058. doi:

31
Mar
2000

Effects of aging on Cholinergic system of rat isolated ileum

R Mortazavi,
F Derakhshan

Mortazavi R, Derakhshan F. Effects of aging on Cholinergic system of rat isolated ileum. J Inflamm Dis. 2024;3(4):e154678. doi:

Import into EndNoteImport into BibTex
Crossmark
Crossmark
Checking
Share on
Comments
Number of Comments:0
Cited by
Metrics
Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC 

Search Relations

Author(s):

Related Articles

Related Article in PubMed

Related Article in Google Scholar

Create Citation Alert via Google Reader