The Effect of Different Surfactants on Dissolution Rate of Recrystallized Indomethacin

Soheila Honary; Abas Majidian; Farzaneh Naghibi

doi:10.22037/ijpr.2010.695

IJ Pharmaceutical Research

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https://doi.org/10.22037/ijpr.2010.695

The Effect of Different Surfactants on Dissolution Rate of Recrystallized Indomethacin

Author(s):

Soheila Honary^1,*,

Abas Majidian¹,

Farzaneh Naghibi²

1Mazandaran University of Medical Sciences, School of Pharmacy, Pharmaceutical Sciences Research center, Sari, Iran

2TMRC, Shaheed Beheshti University of Medical Sciences, School of Pharmacy, Tehran, Iran

IJ Pharmaceutical Research:Vol. 6, issue 1; 25-33

Published online:Jan 01, 2007

Article type:Research Article

Received:Sep 01, 2005

Accepted:Jun 01, 2006

How to Cite:Honary S, Majidian A, Naghibi F. The Effect of Different Surfactants on Dissolution Rate of Recrystallized Indomethacin. Iran J Pharm Res. 2007;6(1):e128306. doi: https://doi.org/10.22037/ijpr.2010.695

Abstract

The effects of crystallization of indomethacin as a poorly water-soluble drug in aqueous surfactant solutions (using the basket method), on the drug dissolution behavior was investigated.A significant enhancement of drug dissolution was observed for for the dissolution rates of crystals treated with hydrophilic surfactants, Tween 80 and sodium lauryl sulfate (SLS). However, asing Arlacel 60 as a hydrophobic surfactant incrystallization medium decreased the indomethacin dissolution rate. Differential scanning calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FT-IR) indicated the existence of both α and γ- polymorphs of indomethacin (with different percentages). The FT-IR results also showed that, only the α- form could be detected in indomethacin crystals without any surfactant. These results were also confirmed by X-ray powder diffraction and scanning electron microscopy (SEM). The nuclear magnetic resonance (NMR) studies demonstrate the presence of a small amount of Tween 80 and the absence of SLS in the treated crystals. In this study, we concluded that, the presence of small amounts of surfactant, adsorption of surfactant onto the crystal surface and the decrease in powder bulk density could be the possible mechanisms of alteration in the dissolution rate of crystals treated with Tween 80, Arlacel 60 and SLS respectively Antioxidant.

Keywords

Indomethacin

Dissolution

Surfactant

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Soheila Honary:[PubMed][Scholar]
Abas Majidian:[PubMed][Scholar]
Farzaneh Naghibi:[PubMed][Scholar]

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The Effect of Different Surfactants on Dissolution Rate of Recrystallized Indomethacin

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