IJ Pharmaceutical Research
Inhibitory Effects of Six Allium Species on α-Amylase Enzyme Activity
Abstract
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. The management of the blood glucose level is a critical strategy in the control of diabetes complications. Inhibitors of carbohydrate hydrolyzing enzymes have been useful as oral hypoglycemic drugs for the control of hyperglycemia especially in patients with type II disables mellitus. The goal of the present study was to investigate the inhibitory effects of six selected Allium species (A. akaka, A. ampeloprasum subsp. iranicum, A. cepa, A. hirtifolium, A. porrum and A. sativum) on α-amylase enzyme using an in vitro model. According to the results, ethanol extracts of A. akaka, A. sativum, A. porrum and A. cepa were found to have a favorable α-amylase inhibitory activity with IC50 values of 16.74, 17.95, 15.73 and 16.36 mg/ml, respectively and they did not reveal any significant differences in their IC50 values (p>0.05). However, the two other Allium species tested (A. ampeloprasum subsp. iranicum and A. hirtifolium) did not show valuable inhibitory activity.
Copyright
© 2022, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Evaluation of Anti-Platelet Aggregation Effect of Some Allium Species
Lorigooini Z, Ayatollahi SA, Amidi S, Kobarfard F. Evaluation of Anti-Platelet Aggregation Effect of Some Allium Species. Iran J Pharm Res. 2015;14(4):e125392. doi: https://doi.org/10.22037/ijpr.2015.1769
Comparison of the Effects of Allium cepa L. Extract Together with Insulin on Sperm Parameters in Diabetic Rats
Nikzad H, Hookari S, Kamani M. Comparison of the Effects of Allium cepa L. Extract Together with Insulin on Sperm Parameters in Diabetic Rats. Jundishapur J Nat Pharm Prod. 2022;17(3):e119516. doi: https://doi.org/10.5812/jjnpp-119516
Hypoglycemic Effects of Three Medicinal Plants in Experimental Diabetes: Inhibition of Rat Intestinal α-glucosidase and Enhanced Pancreatic Insulin and Cardiac Glut-4 mRNAs Expression
Moradabadi L, Montasser Kouhsari S, Fehresti Sani M. Hypoglycemic Effects of Three Medicinal Plants in Experimental Diabetes: Inhibition of Rat Intestinal α-glucosidase and Enhanced Pancreatic Insulin and Cardiac Glut-4 mRNAs Expression. Iran J Pharm Res. 2013;12(3):e125663. doi: https://doi.org/10.22037/ijpr.2013.1335
The effect of oral feeding of Allium ascalonicum L. on thoracic aorta contractile response in diabetic rats
Falahi F, Roghani M, Bagheri A. The effect of oral feeding of Allium ascalonicum L. on thoracic aorta contractile response in diabetic rats. koomesh. 2009;10(3):e152243. doi:
Biomolecular Insights Into the Antifungal Activity of Allium Species Constituents: From Mechanisms to Applications
Eslami S, Zolfaghari B, Sadeghi Dinani M, Ghanadian M. Biomolecular Insights Into the Antifungal Activity of Allium Species Constituents: From Mechanisms to Applications. Iran J Pharm Res. 2025;24(1):e162031. doi: https://doi.org/10.5812/ijpr-162031
Crossmark
Checking
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 88
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 4
Last Update: 1 day ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC