IJ Radiology
MRI is not able to directly measure the concentration of contrast agent. It is measured indirectly from the signal intensity (SI). It is very important to know how much contrast agent should be injected to receive a maximum SI in the region of interest (ROI).
The aim of this study was to investigate the maximum relationship between contrast concentration and signal intensity (SI) on T1-weighted images using spin echo (SE), fast spin echo (FSE) and inversion recovery (IR) sequences.
To assess the relationship between SI and concentration, a water-filled phantom containing vials of different concentrations of gadolinium DTPA (Gd-DTPA) (0 to 19.77 mmol/L) or a constant concentration (1.2 mmol/L) of contrast agent was used. The vials of constant concentration were used to measure coil nonuniformity. The mean SI was obtained in the ROI using T1-weighted images. All studies were carried out using a 0.3 T clinical MR scanner with a standard head coil.
This study shows that maximum SI will appear at different ranges in different sequences. The maximum SI can be seen at concentrations of 5.95, 4.96 and 3.98mmol/L for SE, FSE and IR, respectively.
Using standard imaging parameters, each MRI sequence reaches its maximum SI in a specific contrast concentration, which is highest in SE and least in IR in a comparison between SE, FSE and IR sequences.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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Gharehaghaji N, Nazarpoor M, Saharkhiz H. Effect of Flip Angle on the Correlation Between Signal Intensity and Different Concentrations of Iron Oxide Nanoparticles Using T1-Weighted Turbo-FLASH Inversion Recovery Sequence. I J Radiol. 2015;12(2):e22887. doi: https://doi.org/10.5812/iranjradiol.22887
Mohammadzadeh M, Sheibani Z, Shakiba M, Azimi AR, Hashemzadeh A, et al. Evaluation of the Effect of Multiple Linear Gadolinium-Based Contrast Agent Exposures on the Signal Intensity of the Dentate Nucleus in Multiple Sclerosis Patients. I J Radiol. 2021;18(4):e114397. doi: https://doi.org/10.5812/iranjradiol.114397
Fan B, Li M, Wang X, Xu Y, Li F, et al. Time-Dependent Changes in the Magnetic Resonance Detection of Brain Metastases Using Single-Dose Gadobutrol. I J Radiol. 2018;15(1):e66054. doi: https://doi.org/10.5812/iranjradiol.66054
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