Logo
homeHome
toggle_offCompany ProfilegroupsBoards & Staffsworkspace_premiumMemberships & PartnersschoolAcademy of Journalismperson_addCareerslinkBlog(EN)emailContact Us
list_altOur JournalslightbulbInstruction for AuthorsbookmarkBrieflands PolicieshandshakePublish My Researchplay_circleJournal Management Systemcredit_cardArticle Processing Chargeszoom_inOpen Peer ReviewimagePublishing Services
menu_bookPublish My Book

IJ Radiology

An Innovative Journal in the Field of Radiology

homeHome
play_arrowCurrent IssuelistAll Issuesformat_indent_increaseIn Presscheck_circleAccepted ManuscriptssearchSearch
helpInstructions
bookmarkJournal InformationgroupsEditors and BoardsshareIndexing and Listing Sourcesshow_chartJournal Metricszoom_inOpen Peer Review (OPR)balancePublication Ethics and Malpractice Statementassignment_indReviewer and AE Registration FormemailSupportphoneContact Us
format_list_bulletedAPC
Authors GuideSubmit Manuscript

Outlines

https://doi.org/10.5812/iranjradiol.48036

Apparent Diffusion Coefficient Value as a Predictive Marker to Evaluate Tumor Response in Patients with Cervical Cancer

Author(s):
Fariba AllahmoradiFariba Allahmoradi1,*, Abbas HaghparastAbbas Haghparast1, Salman ZakariaeeSalman Zakariaee2
1Kermanshah University of Medical Sciences, Kermanshah, Iran
2Tehran University of Medical Sciences, Tehran, Iran
IJ Radiology:Vol. 14, issue Special Issue; e48036
Published online:Apr 12, 2017
Article type:Abstract
Received:Dec 20, 2016
Accepted:Feb 07, 2017
How to Cite:Allahmoradi F, Haghparast A, Zakariaee S. Apparent Diffusion Coefficient Value as a Predictive Marker to Evaluate Tumor Response in Patients with Cervical Cancer. I J Radiol. 2017;14(Special Issue):e48036. doi: https://doi.org/10.5812/iranjradiol.48036

Abstract

Background:

Cervical cancer is the second common cancer and the third reason of mortality among women in the world which is often occurred in third and fifth decades of their life. Cervical tumor recurrence observed in 30% of the patients and the 5-years survival rate of cervical cancer is about %50. The development of a rapid and non-invasive method for treatment response evaluation is one of the most challenges in cancer treatment management.Diffusion-weighted magnetic resonance imaging (DW-MRI) is a contrast agent free imaging technique thatis widely used for oncology studies.

Objectives:

In this paper, thecapability of ADC valueto monitor the treatmentresponse in the cervical cancer patientswasevaluated.

Methods:

A computerized search using the databases SID, Google Scholars, Pub med and Science Direct, covering the period from 1998 to 2015, was conducted using the following key search terms: Treatment response, Diffusion-weighted magnetic resonance imaging, ADC, MRI and Cervical Cancer. In total, 27 relevant papers were reviewed.

Results:

Studies had shown thatthe mean ADC value of cervical carcinoma (1.110 0.175 10-3 mm2/s)is significantly lower than that of normal cervical tissue (1.593 0.151 10-3 mm2/s) (P < 0.001). The mean ADC value of the cervical area significantly increased after chemoradiationtreatment (1.436 0.129 10-3 mm2/s) than that before therapy (1.013 0.094 10-3 mm2/s) (P < 0.001). There is a statistically significant difference between the ADC values of the normal cervical tissue and cervical area after therapy (P < 0.01). Partial response of the bulky tumorscould be predicted with high sensitivity (85.7%) and specificity (100%) (AUC 0.96; P = 0.05) using the ADC value greater than 0.95 10-3 mm2/s.

Conclusions:

ADC valuecould be a prognostic factor to monitor the response to therapy for patients with cervical cancer. The addition of DW-MRI to the conventional MRI protocolsconsiderably improved the diagnostic ability of MR imaging method for tumor evaluations.

Keywords
Treatment Response
Diffusion-Weighted Magnetic Resonance Imaging
DW-MRI
ADC
Cervical Cancer

Full Text

Full text is available in PDF
Import into EndNoteImport into BibTex
Crossmark
Crossmark
Checking
Share on
Comments
Number of Comments:0
Cited by
Metrics
Get Permission (article level)

Purchasing Reprints

  • Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here (   https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations

Author(s):

Related Articles

Related Article in PubMed

Related Article in Google Scholar

Create Citation Alert via Google Reader