Does Myocardial Scan with Technetium Lead to Radio Adaptive Response Among Patients Who Are Undergoing Thallium Scan? (Cytogenetic Study)

Mohammmad Mehdi Shirazi; Ali Shabestani Monfared; Maryam Shahidi; Mehrangiz Amiri

doi:10.5812/iranjradiol.48207

Iranian Journal of Radiology

An Innovative Journal in the Field of Radiology

e-ISSN 2008-2711

p-ISSN 1735-1065

Cover image of the article: Does Myocardial Scan with Technetium Lead to Radio Adaptive Response Among Patients Who Are Undergoing Thallium Scan? (Cytogenetic Study)

Image Credit:I J Radiol

Outline

Abstract
Copyright

https://doi.org/10.5812/iranjradiol.48207

Does Myocardial Scan with Technetium Lead to Radio Adaptive Response Among Patients Who Are Undergoing Thallium Scan? (Cytogenetic Study)

Authors

Mohammmad Mehdi Shirazi^1,*, Ali Shabestani Monfared¹, Maryam Shahidi², Mehrangiz Amiri¹

1Babol University of Medical Sciences, Babol, Iran

2Mazandaran University of Medical Sciences, Mazandaran, Iran

*Corresponding Author: Babol University of Medical Sciences, Babol, Iran, Shirazi_1200@yahoo.com. Email: Shirazi_1200@yahoo.com

Iranian Journal of Radiology:Vol. 14, issue Special Issue; e48207

Published online:Apr 12, 2017

Article type:Abstract

Received:Dec 20, 2016

Accepted:Feb 07, 2017

How to Cite:Shirazi MM, Shabestani Monfared A, Shahidi M, Amiri M. Does Myocardial Scan with Technetium Lead to Radio Adaptive Response Among Patients Who Are Undergoing Thallium Scan? (Cytogenetic Study). I J Radiol. 2017;14(Special Issue):e48207. doi: https://doi.org/10.5812/iranjradiol.48207

Abstract

Background:

Low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. This phenomenon is known as radio-adaptive response. The aim of this study was to investigate the percentage of apoptotic cells in the peripheral blood samples of the patients which undergo myocardial perfusion imaging with Tc-99m prior to thallium scan to assess the induction of radio-adaptive response.

Methods:

97 samples from 74 patients, referred to nuclear medicine center of Mazandaran heart hospital for myocardial perfusion imaging which had no history of diagnostic, therapeutic, occupational and radioactive exposures during past two years, were provided. The participants were classified into four groups including control, technetium, thallium and the last group were the patients that examined by technetium followed by thallium. Then 2 mL Peripheral blood samples were obtained, the samples were studied by neutral comet assay with one-way ANOVA.

Results:

The mean percent of apoptotic cells in the groups 2, 3, 4 were more than the controls and the mean percent of apoptotic cells in the patients who examined with 201Tl were more than other groups but the mean percent of apoptotic cells in the group 4 (99mTc before 201Tl) was less than that group 3(just examinated by 201Tl) and this difference was significant statistically.

Conclusions:

These findings suggest that exposure to Tc-99m could induce a radio-adaptive response against the exposure of Tl-201.

Highlights

KeywordsMyocardial Perfusion Imaging Radio-Adaptive Response Technetium Thallium

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© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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