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International Cardiovascular Research Journal
An annual journal in scientific affiliation with the Cardiovascular Research Center, Shiraz University of Medical Sciences
e-ISSN 2251-9149
p-ISSN 2251-9130
Image Credit:Int Cardiovasc Res J
Outline
Upregulation of Ryanodine Receptor Calcium Channels (RyR2) in Rats with Induced Diabetes after 4 Weeks of High Intensity Interval Training
Authors
Mohammad Ali Babaee Bigi1, Hossein Faramarzi 2, Abbas Ali Gaeini 2, Ali Asghar Ravasi3, Mohammad Reza Izadi3,*, Maryam Delfan3, Esmaeil Izadi3
1Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Larestan School of Medical Science, Larestan, Iran
3Faculty of Sport Science, Tehran University, Tehran, Iran
*Corresponding Author: Corresponding author: Mohammad Reza Izadi, Faculty of Sport Science, Tehran University, Tehran, Iran Email: izadi.mreza@gmail.com
Published online:Mar 01, 2016
Article type:Research Article
Received:May 09, 2015
Accepted:Sep 01, 2015
How to Cite:Babaee Bigi MA, Faramarzi H, Gaeini AA, Asghar Ravasi A, Izadi MR, et al. Upregulation of Ryanodine Receptor Calcium Channels (RyR2) in Rats with Induced Diabetes after 4 Weeks of High Intensity Interval Training. Int Cardiovasc Res J. 2016;10(1):e10311. doi:
Abstract
Background: To date, not sufficient information is available regarding the effect of High Intensity Interval Training (HIIT) on diabetes-induced myocardial dysfunctions.
Objectives: The present study aimed to evaluate the effect of 4-week HIIT on change in expression levels of ryanodine receptor calcium channel (RyR2) and ATPase calcium pump (SERCA2a) in diabetic rats.
Materials and Methods: This study was conducted on 24 Wistar rats with average weight of 245 ± 10 g. The rats were randomly divided into a sedentary diabetic group and a trained diabetic group. Training was started two weeks after diabetes induction by Streptozotocin (STZ) injection. The training program consisted of 4 weeks running on a treadmill and was considered to be intense for the two groups’ diabetic rats. After all, the animals’ characteristics and myocardial gene expression were compared using independent t-test.
Results: Measurement of gene expression by Real Time-PCR revealed that cardiac mRNA expression of RyR2 was enhanced in the HIIT group. The results also revealed a significant (P = 0.03) difference between the hearts of the sedentary controls and the trained group regarding RyR2 levels. However, no significant difference was observed between the two groups with respect to SERCA2a levels (P = 0.14).
Conclusions: The study results showed that treatment with HIIT could prevent and/or minimize the loss in expression of RyR2 and SERCA2a.
Highlights
References
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Copyright
© 2016, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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